Preterm neonates, Premature infants, parenteral nutrition, tolerance
Conditions
Interventions
Intervention group A will receive lipids from birth onwards. Interventiongroup B will receive extra amino acids in combination with lipids from birth onwards. The control group will be fed according t
Sponsors
Erasmus Medical Center - Sophia Children's Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Inborn, Gestational weight less than 1500g
Exclusion criteria
Exclusion criteria: 1. Congenital anomalies 2. Metabolic disease 3. Endocrine, renal or hepatic disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nitrogen balance | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Safety of the nutritional regimen: as reflected by normal blood chemistry, no effect on hearing ability, no effect on chronic lung disease; 2. Growth: measured in terms of body weight, knemometry, head circumference, protein accretion and protein breakdown; 3. Fatty acid profile in plasma and erythrocytes; 4. Energy expenditure; 5. Short- and long-term outcome: days on mechanical ventilation, incidence of bronchopulmonary dysplasia, incidence of infection, intraventricular hemorrhage, and necrotizing enterocolitis, normal ALGO-test and Bayley III scores | — |
Contacts
Public ContactJ.B. Goudoever, van
Erasmus Medical Center, Sophia Children's Hospital P.O. Box 2060
Outcome results
None listed