Non-affective psychotic disorder. Niet-affectieve psychotische stoornis. Titel: Deployment of dedicated nursing staff to stimulate use of clozapine. Hypothese: Physicians in teams of Type/Condition A (where they can delegate clozapine monitoring tasks to a Nurse Practitioner) will prescribe clozapine more often than physicians in teams of Type/Condition B (where they should performing monitoring tasks themselves). Blindering: Single-blind Primaire uitkomst: Proportion of patients indic
Conditions
Interventions
1. Education of physicians and NPs about indications for clozapine.
2. Physicians and NPs screen all patients in their team for a possible indication for clozapine. 3. Randomization of teams into con
Sponsors
Rivierduinen, GGZ Leiden, the Netherlands and Maastricht University, the Netherlands.
Eligibility
Inclusion criteria
Inclusion criteria: Teams: - Outpatient teams in which a nurse practitioner participates Patients: - Age 18-55 - Diagnosis: non-affective psychotic disorder
Exclusion criteria
Exclusion criteria: NA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1a. Proportion of missed weekly lab exams (white blood cells) in condition A vs. B. 1b. Number of days the lab exams (white blood cells) are delayed, divided by total number of required lab exams in condition A vs. B. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of clozapine use in condition A vs. B. 2. Clinical Global Impression-Schizophrenia scale (CGI-SCH) score of change in condition A vs. B. 3. Proportion of patients indicated for clozapine (in condition A vs. B) who actually start with this drug. 4. Proportion of patients for whom clozapine is indicated. 5. Qualitative data to explore how potentially hazardous side-effects were handled. | — |
Contacts
Public ContactYvonne van der Zalm
GGZ Leiden
Outcome results
None listed