Hypertension High blood pressure Proteins Hoge bloeddruk Hypertensie Eiwitten
Conditions
Interventions
First 2 weeks weight maintaining standardized diet (15 en% protein, 30 en% fat and 55 en% carbohydrates). Next 6 weeks weekly clinical investigation days on which the acute postprandial effects of dif
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Men and women; 2. BMI 25-35 kg/m2; 3. High normal BP or untreated grade 1 hypertension (SBP 130-159 mm Hg and/or DBP 85-99 mm Hg); 4. Age between 20 - 70 years; 5. No smoking; 6. Stable weight in last 3 months (+/- 2 kg).
Exclusion criteria
Exclusion criteria: 1. Presence of urinary protein; 2. eGFR 7 mmol/l; 4. Use of prescription medication that could influence BP or vascular function; 5. Gastrointestinal, cardiovascular, pulmonary, liver or renal disease; 6. Food allergies, a special diet or vegetarian; 7. Unwillingness to stop use of vitamin or dietary supplements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute TPR response (derived according to the equation; MAP = CO x TPR) on each clinical investigation day during first 4 hours after consumption of supplements. Mean Arterial Pressure (MAP) and Cardiac Output (CO) will be measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute responses on renal sodium excretion, vasodilating factors and vascular function changes on each clinical investigation day during first four hours after consumption of supplements. | — |
Contacts
Public ContactJ. Dopheide
Maastricht University Dep. Human Biology P.O. Box 616
Outcome results
None listed