Classic Galactosemia
Conditions
Interventions
We propose a pre/during/post stimulated mixed design in CG and healthy controls. The intervention consists of tACS at beta and theta frequency in two different sessions to hopefully ameliorate the mot
Sponsors
azM
Eligibility
Inclusion criteria
Inclusion criteria: Patient group The patient may participate in the study, if they meet these criteria: - Adult age: 18 years or older - GALT enzyme activity below 10% and/or GALT gene severe disease causing mutations - Motor sequencing and/or word productions problems - Documented motor and language impairments - Capable of giving informed consent - The participants are screened pre and post intervention using standardized tests. Participants with abnormal scores in cognitive and/or motor domains are eligible. Control group Healthy controls are included if they meet the following criteria: - Adult age: 18 years or older - No motor, language and/or cognitive impairments - Capable of giving informed consent
Exclusion criteria
Exclusion criteria: A subject will be excluded from the study, if he meets these criteria: - Motor and language problems due to other causes - Eczema - Psoriasis - Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We propose a proof of concept study to apply noninvasive brain stimulation, specifically tACS, for the first time to adult CG patients with the aim to find stimulation protocols that improve their motor and language performance by positively influencing their brain oscillatory profiles. Thereby we hypothesize that tACS can entrain oscillations in individual and relevant frequencies such that they result in improvements of their motor and language performance. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To benchmark individual brain oscillations in CG for the first time and compare them to those of healthy controls. 2) To apply these individualized frequencies with tACS to entrain the relevant brain oscillation 3) To compare EEG and behavior pre and post stimulation to quantify the effect and efficiency of NIBS in CG | — |
Contacts
Public ContactBritt Derks
MUMC+
Outcome results
None listed