Parkinson's disease
Conditions
Interventions
None listed
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: All subjects: - Dutch speaking - In possession of a driver’s license - Active drivers, i.e., having driven at least 300 kilometres in the last year - Age 18 to 75 - Willingness to cooperate and sign written informed consent De novo PD subjects: - Diagnosis Parkinson’s disease, as confirmed by a neurologist specialized in Parkinson’s Disease, by the UK-Brain Bank Criteria. - Disease duration < 3 months, measured after time of diagnosis.
Exclusion criteria
Exclusion criteria: All subjects: - Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness. - Use of category III medication. De novo PD subjects: - History of dopaminergic medication use. - Presence of premorbid pathology, i.e. experienced cerebral infarction or chronic depression, non-related to Parkinson’s disease. Healthy control subjects: - Presence of psychiatric disorders, i.e. depression or psychosis. - History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic strokes).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Driving simulator performance of de novo PD patients compared to HC, using the SDLP during Swing Drive part 1. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures will be other driving simulator variables (e.g. speed, percentage of lane crossing, reaction time to triggered events and number of violations) and the identification of correlates between SDLP and potential predictors, i.e. neuropsychological test scores and motor scores. | — |
Contacts
Public ContactHanna Slomp
University Medical Center Groningen
Outcome results
None listed