Esophageal cancer, esophagectomy, postoperative complications, cardiopulmonary complications, anastomic leakage, Quality of Life
Conditions
Interventions
Nitrate-rich Beet It Sport shot (70cc) versus nitrate-depleted Beet It Sport shot (placebo, 70cc). Depending on randomization patients will be take 1 bottle once daily for seven consecutive days direc
Sponsors
Catharina Hospital Eindhoven
Eligibility
Inclusion criteria
Inclusion criteria: - Prehabilitated patients undergoing an elective minimally invasive Ivor-Lewis esophagectomy with intrathoracic anastomosis - Written informed consent - Age >18 years
Exclusion criteria
Exclusion criteria: Allergy to beets/BRJ Inability to tolerate oral intake, e.g. swallowing disorder Inability to follow the PREPARE program Inability to provide written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Predicted VO2max (ml/kg/min) | — |
Secondary
| Measure | Time frame |
|---|---|
| - All 30-day and in-hospital postoperative complications specifically: > Cardiopulmonary complications - Other PREPARE measurements, e.g.: Maximum power output/wattage (Wmax) > Predicted VO2peak (ml/kg/min) > Maximum inspiratory pressure (MIP) > Spirometry measurements (e.g. forced expiratory volume in 1 second; FEV1) - Functional recovery, total length of hospital and ICU stay and readmission rate - Quality of life (EuroQol EQ-5D-5L and EORTC QLQ-C30 validated questionnaires) | — |
Contacts
Public ContactThijs Janssen
Catharina Ziekenhuis Eindhoven
Outcome results
None listed