Pancreatic ductal adenocarcinoma (PDAC)
Conditions
Interventions
Peripheral venous blood draws, appendectomy during standard of care (laparoscopic) surgery, liver and peritoneal biopsies if metastases are visualized during staging laparoscopy
Sponsors
Department of Surgery, Erasmus Medical Center Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older with treatment naïve pancreatic ductal adenocarcinoma who will either undergo staging laparoscopy for locally advanced disease, or tumor resection for (borderline) resectable disease.
Exclusion criteria
Exclusion criteria: prior appendectomy, prior malignancy within the past 5 years, prior chemotherapy or radiotherapy within the past 5 years, pregnancy, participation in the PREOPANC-2 trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of PDAC-specific oncolytic activity of vermiform appendix derived T lymphocytes | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of - PDAC specific antigens - appendix fecal microbiome diversity - molecular immune landscapes in the vermiform appendix sana from patients with PDAC compared to controls - differential T-cell and B-cell receptor repertoires in peripheral blood lymphocytes vs lymphocytes from the vermiform appendix, in patients with PDAC. | — |
Contacts
Public ContactEveline Vietsch
Erasmus Medisch Centrum Rotterdam
Outcome results
None listed