Panic Disorder CO2 challenge interoceptive stimuli interoceptive conditioning
Conditions
Interventions
We want to establish intero-interoceptive fear conditioning with a differential conditioning paradigm. We want to make use of “real” interoceptive conditioned stimuli (CS): A low respiratory load (1.
Sponsors
performer= University of Maastricht
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers aged between 18-65 years; 2. Good physical condition.
Exclusion criteria
Exclusion criteria: 1. History of pulmonary disease (including asthma and lung fibrosis); 2. A psychiatric disorder; 3. History of cardiovascular disease (including cardiac failure, suspicion of infarct, cardiomyopathy, TIA, angina pectoris, arrythmias); 4. Hypertension (diastolic > 100; systolic > 170); 5. Personal or familial history of cerebral aneurysm; 6. Pregnancy; 7. Epilepsy; 8. Psychotropic medication use; 9. Use of á2- or â-blockers; 10. Idiosyncratic response to pentagastrin; 11. If participants refuse insight in deviant findings.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The subjective reports of the participants measured by the Visual Analogue Scale – Fear (VAS-F) during the test part. | — |
Secondary
| Measure | Time frame |
|---|---|
| The physiological responses of respiration rate, tidal volume and FetCO2 and the subjective report by Panic Symtom List (PSL) during the test part. | — |
Contacts
Public ContactKoen Schruers
Postbus 88
Outcome results
None listed