human thermoregulation, thermoregulatory behaviour, thermophysiology, mild heat, mild heat acclimation, acclimation
Conditions
Interventions
The study will take place between March 2014 and December 2015. The measurements will be conducted at the Metabolic Research Unit (MRUM) of Maastricht University. The study will consist of 11 testing
Sponsors
Maastricht University Medical Center+
Eligibility
Inclusion criteria
Inclusion criteria: Caucasian healthy lean volunteers • Generally healthy • male or female • Age: 18 to 35 years • BMI: 20-25 kg/m2 • Women using Microgynon 30 or levonorgestrel/ehinylestradiol Inclusion criteria obese volunteers • Generally healthy • male or female • Age 18 to 35 years • BMI 28-35 kg/m2 • Women using Microgynon 30 or levonorgestrel/ethinylestradiol
Exclusion criteria
Exclusion criteria: • Participants that do not want to be informed about accidental medical findings, which might occur during the study. o If participants do not want us to inform their general practitioners about unexpected medical findings, they cannot participate in the study. • Participate in physical activity more than 2x/week o We will exclude individuals that participate in endurance sports (like swimming, running, cycling) more than two hours per week. Endurance-trained athletes seem to have differing thermo-physiology, which has, amongst others, been recently confirmed by another study of our laboratory (Vosselman et al, submitted). • Participation in another biomedical study within 1 month before the first screening visit • Diabetes mellitus type I and II • Pregnancy • Unstable weight (weight gain or loss > 5 kg in the last three months) • Hypertension (systolic/diastolic blood pressure >140/90) • Hypotension (systolic/diastolic blood pressure <90/60) • General feeling of illness at day of experiment • (History of) cardiovascular diseases • Contraindications for the telemetric pill: o In the presence of any known or suspected obstructive disease of the gastrointestinal tract, including but not limited to diverticulitis and inflammatory bowel disease o A history of disorders or impairment of the gag reflex o Previous gastrointestinal surgery o Hypo motility disorders of the gastrointestinal tract including but not limited to Illeus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thermoregulatory behavior, thermal sensation, thermal comfort, thermo-physiological parameters (energy expenditure, core temperature, skin temperature, skin blood perfusion, local sweat rate, total sweat rate, skin conductance, shivering) and body composition | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiovascular functions such as heart rate, blood pressure, hemodynamic parameters, blood parameters, gross motor activity and alertness | — |
Contacts
Public ContactH. Pallubinsky
Universiteitssingel 50
Outcome results
None listed