Disrupting the rhythm of depression.

“Effectiveness and cost-effectiveness of brief preventive cognitive therapy versus maintenance antidepressant treatment to prevent relapse in recurrent depression: a randomized controlled multi-center trial”.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20158

Enrollment

276

Registered

2009-07-14

Start date

2009-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder, relapse, recurrence, cognitive therapy, prevention, cost-effectiveness Depressie, terugval, cognitive therapie, preventie, kosteneffectiviteit

Interventions

Brief CT (while tapering AD) versus continuation of AD use versus brief CT combined continuation of AD.

Eligibility

Inclusion criteria

Inclusion criteria: Remitted patients on AD with at least two previous depressive episodes in the past five years.

Exclusion criteria

Exclusion criteria: 1. Current mania or hypomania or a history of bipolar illness; 2. Any psychotic disorder (current and previous); 3. Organic brain damage; 4. Alcohol or drug misuse; 5. Predominant anxiety disorder.

Design outcomes

Primary

Measure	Time frame
Time related proportion of depression relapse/recurrence during 15-24 months using DSM-IV-R criteria as assessed by the Structural Clinical Interview for Depression.	—

Secondary

Measure	Time frame
1. Cost-effectiveness; 2. Number, duration and severity of relapses/recurrences; 3. Potential mediators of the effect.	—

Contacts

Public ContactC.L.H. Bockting

Rijksuniversiteit Groningen Klinische Psychologie Grote Kruisstraat 2/1

c.l.h.bockting@rug.nl+31 (0)50-3636479

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)