Intraventricular haemorrhage caused by extension of intracerebral haemorrhage.
Conditions
Interventions
External ventricular drain(s) placement. Infusion of 3 mg tr-PA through the EVD twice daily with a maximum of six days, compared to extraventricular drainage alone.
Sponsors
Geen sponsor.
Geinitieerd door de afdeling neurologie van het AMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. IVH caused by extension of spontaneous ICH confirmed by CT-scan; 3. Glasgow Coma Score on admission of < 14; 4. Able to include patients within 48 hours after ICH onset; 5. Historical mRankin of 0 or 1.
Exclusion criteria
Exclusion criteria: 1. IVH caused by aneurysm or arteriovenous malformation as seen on CT-scan; 2. Only sedimentation of blood in the lateral ventricles; 3. Infratentorial bleeding; 4. Evacuation of parenchymal hematoma is deemed necessary; 5. Clotting disorder; 6. Pregnancy; 7. Epileptic seizure at onset; 8. Absence of brain stem reflexes on admission; 9. If death appears imminent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Poor outcome at three months (mRankin scale and GOS). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Drain dependency at 3 months; 2. Amsterdam Linear Disability Scale score at 3 months; 3. Intraventricular or parenchymal bleeding complications; 4. Ventriculitis. | — |
Contacts
Public ContactK. Gans, de
Acedemic Medical Center (AMC), Department of Neurology, P.O. Box 22660
Outcome results
None listed