Functional Dyspepsia (FD)
Conditions
Interventions
1. Amitriptyline or placebo for the patient group (see the amitriptyline study)
2. Single Photon Emission Computed Tomography (SPECT) imaging with [123I] IBZM radioligand
3. Alpha-methyl-paratyrosine (AMPT, =metyrosine) challenge test. 2x 500 mg.
Sponsors
Academic Medical Center (AMC) amsterdam, department of gastroenterology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years; 2. Functional dyspepsia (NDI>25); 3. Take part in the amitriptyline study; 4. No effect of PPI or 3 months constantly the same doses; 5. No depression (ZUNG<50); 6. No medications which influence the intestine.
Exclusion criteria
Exclusion criteria: 1. Gastroduodenal surgery; 2. Reflux-like dyspepsia (Rome II criteria); 3. Use of antidepressivants; 4. Organic abnormalities; 5. Pregnancy; 6. Severe cardiac, renal, pulmonary, hepatic or systemic diseases. Hyperthyroidism, glaucoma and epilepsy; 7. Metal implantates.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate if patients with functional dyspepsia have a change in their dopaminergic system what leads to visceral hypersensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Has amitriptyline a positive effect on those changes in the dopaminergic system through reducing the stress? | — |
Contacts
Public ContactG.E.E. Boeckxstaens
Academic Medical Center (AMC), Department of Gastroenterology, C2-328, P.O. Box 22660
Outcome results
None listed