This concerns a study in healthy volunteers aiming to study a mechanism driving behaviour.
Conditions
Interventions
methylphenidate and acute stress
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: - good physical and mental health as determined by medical history and medical examination, ECG and laboratory examination; - BMI between 18 and 25 m2/kg; - written informed consent; - age between 18-35 (inclusive) - educational level: at least having finished secondary school
Exclusion criteria
Exclusion criteria: - pregnancy or lactation, or plans to get pregnant in the near future; - cardiovascular abnormalities as assessed by standard ECG; - excessive alcohol use, defined as drinking more than 21 glasses of alcohol per week; - history of drug abuse or addiction; - hypertension (diastolic> 90; systolic> 140); - history of psychiatric and neurological disorders - current use of psychoactive medication or medication known to affect stress responding (e.g., beta-blockers; for women, the use of oral contraceptives is allowed). - Contraindications to methylphenidate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| behavioural performance on an instrumental learning task and functional connectivity measures derived from fMRI data. | — |
Secondary
| Measure | Time frame |
|---|---|
| behavioural inhibitory control and unconscious learning measures. Endocrine stress markers. | — |
Contacts
Public ContactPeter van Ruitenbeek
Clinical Psychological Science, Maastricht University
Outcome results
None listed