Epilepsy
Conditions
Interventions
Not applicable.
Sponsors
Medisch Spectrum Twente
Eligibility
Inclusion criteria
Inclusion criteria: • Adult (=18 year) patients with medically refractory epilepsy, who are candidates for ANT-DBS or who already have an ANT-DBS implant. • Implantable pulse generator (IPG) that allows recording of LFPs (Medtronic Percept system).
Exclusion criteria
Exclusion criteria: • Patients with cognitive impairments that causes the patient to be unable to understand the research purpose and give informed consent wilt be excluded in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary goal of the study is to identify biomarkers from LFPs recorded from the DBS electrodes that are associated with treatment response to DBS in patients with epilepsy. Hereby, treatment response is defined by the percentual seizure reduction. | — |
Secondary
| Measure | Time frame |
|---|---|
| • To predict success of DBS in patients with epilepsy using pre-operative features from resting-state 64-channel EEG and MRI. We wilt initially aim to predict responders (>50% seizure reduction at 12 and 24 months after DBS implantation); this binarized response wilt be complemented by assessing the likelihood of seizure reduction on a continuous scale. • To improve insight in the role of the thalamocortical network in patients with epilepsy by studying the relation of simultaneous measured LFP recording of the ANT and 64-channel surFace EEG recording. • To study differences in network characteristics derived from 64-channel EEG, and MRI before and after DBS. • To evaluate the effect of DBS on psychological well-being including quality of life, anxiety, and depression. • To evaluate the effect of ANT DBS on memory functions (pre- vs post-implantation). | — |
Contacts
Public ContactRosalie Visser
Medisch Spectrum Twente
Outcome results
None listed