fat characteristics before and after weightloss: implications for atrial fibrillation’

The change of adipose tissue characteristics upon drastic weight loss: Implications for atrial fibrillation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20084

Enrollment

Registered

2018-04-26

Start date

2018-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity, atrial fibrillation, adipose tissue, electrophysiology, metabolism, epicardial, paracardial, CT-scan

Interventions

1. Adipose tissue biopsies during bariatric surgery 2. Blood extraction pre operative and during follow-up 3. CT scan pre-operative and during follow-up

Eligibility

Inclusion criteria

Inclusion criteria: - Patient undergoing bariatric surgery (BMI above 35) - Age above 40

Exclusion criteria

Exclusion criteria: - Taking 2 or more antihypertensiva - Taking metformine for diabetes - Heart diseases, for example myocardinfarct in past

Design outcomes

Primary

Measure	Time frame
multiple outcomes to identify intra-individual changes of clinical and biochemical markers of AT characteristics upon drastic weightloss: - AT mass, distribution and ratios (EAT, PAT,VAT) - Circulating AT derived protein biomarkers, including: inflammatory markers - Circulating AT derived miRNAs - Locally AT derived protein biomarkers, extracted from VAT. Markers similar to those in circulation. - Locally AT derived miRNAs extracted from VAT. - Anthropometric measurements: height, weight, BMI, waist-circumference, hip-waist ratio. - Occurrence/absence of AF by an approved 7 days rhythm monitoring system. - International Physical Activity Questionnaire.	—

Measure

Time frame

multiple outcomes to identify intra-individual changes of clinical and biochemical markers of AT characteristics upon drastic weightloss: - AT mass, distribution and ratios (EAT, PAT,VAT) - Circulating AT derived protein biomarkers, including: inflammatory markers - Circulating AT derived miRNAs - Locally AT derived protein biomarkers, extracted from VAT. Markers similar to those in circulation. - Locally AT derived miRNAs extracted from VAT. - Anthropometric measurements: height, weight, BMI, waist-circumference, hip-waist ratio. - Occurrence/absence of AF by an approved 7 days rhythm monitoring system. - International Physical Activity Questionnaire.

—

Contacts

Public ContactEva Meulendijks

e.r.meulendijks@amc.uva.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)