Recurrent Pregnancy Loss
Conditions
Interventions
Sponsors
Leiden University Medical Center / Leiden University
Eligibility
Inclusion criteria
Inclusion criteria: Cases: Unexplained recurrent pregnancy loss (according to ESHRE guideline RPL 2017) Controls: = 1 spontaneous miscarriage, proven fertility (i.e. pregnant at inclusion or previously experienced pregnancy in same relationship)
Exclusion criteria
Exclusion criteria: Cases: 1) known causes for RPL (parental chromosomal chromosomal abnormalities, uterine anomalies, acquired or hereditary thrombophilia, hyperhomocystenaemia and untreated or instable endocrine disease); 2) mentally or legally incapibility of either male or female; 3) treatment with oocyte, embryo or spermatozoa donation; 4) loss of < 2 pregnancies in current relationship Controls: 1) any known cause for RPL as described above; 2) mentally or legally incapibility of either male or female; 3) treatment with oocyte, embryo or spermatozoa donation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Case-control study: paternal age Cohort study: development of live birth within 5 years after initial consultation | — |
Secondary
| Measure | Time frame |
|---|---|
| Case-control study: BMI, smoking, alcohol consumption, recreational drug consumption, physical exercise, sperm DNA fragmentation level, immunomodulatory factors in blood and seminal fluid Cohort study: Development of ongoing pregnancy (>24 weeks), time interval until next pregnancy, development of pregnancy complications such as growth restriction, preterm delivery and preeclampsia | — |
Contacts
Public ContactNadia du Fossé
Leiden University Medical Center
Outcome results
None listed