Defining the ventilatory response to hypoxia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON20072

Enrollment

Registered

2008-03-21

Start date

2008-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Control of breathing - physiology

Interventions

Our primary outcome is the ventilatory response to hypoxia. To that end, hypoxia will be induced by lowering the inspired oxygen concentration using a computer-controlled dynamic end-tidal forcing sy

3. A 10-min ramp decrease in oxygen concentration at three end-tidal CO2 levels (total duration 30 min). Continuous measurements will be: oxygen saturation, ventilation (on a breath-to-breath basis)

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers 18-45 years of age

Exclusion criteria

Exclusion criteria: 1. Obesity (BMI > 30) 2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Possibility of pregnancy 6. Lactation

Design outcomes

Primary

Measure	Time frame
Change in ventilation during induction of mild to moderate hypoxia	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)