early esophageal adenocarcinoma vroege slokdarmkanker
Conditions
Interventions
sentinel node procedure, followed by esophagectomy and gastric tube reconstruction
Sponsors
Academic Medical Center Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: - Early esophageal adenocarcinoma, staged as T1 (confined to the mucosa or submucosa) - Clinical condition allowing esophagectomy - Signed informed consent
Exclusion criteria
Exclusion criteria: - Esophageal squamous cell carcinoma - Neo-adjuvant (chemo)radiation therapy - other primary tumor - Known allergy for the radioactive tracer (technetium) - Previous esophageal surgery interfering with the procedure - Comorbidity interfering with the procedures - Unable to provide signed informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Percentage of patients with a detectable sentinel node, either on SPECT/CT or probe-based - Concordance of pre-operative SPECT/CT and perioperative probe-based detection of sentinel nodes - Number of resected sentinel nodes, location documented - Number of resected (non-sentinel) lymph nodes, subdivided per lymph node station - Ratio of number of dissected sentinel nodes and number of detected sentinel nodes on imaging | — |
Secondary
| Measure | Time frame |
|---|---|
| - Procedure time of sentinel node navigation surgery - Number of tumor-positive lymph nodes, subdivided per lymph node station - Adverse events | — |
Contacts
Public ContactH. Künzli
Meiberdreef 9
Outcome results
None listed