Lipid-induced mitochondrial dysfunction in type 2 diabetes.

Skeletal Muscle Insulin Resistance: potential mechanisms and effect of weight-loss and exercise.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON20007

Enrollment

Registered

2009-10-22

Start date

2005-01-02

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes, first-degree relatives of type 2 diabetic patients, insulin resistance, mitochondrial function

Interventions

No intervention is performed.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Well controlled type 2 diabetic patients; 2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes; 3. Normoglycemic control subjects; 4. BMI 27 - 30 kg/m2; 5. Age 50- 70 y.

Exclusion criteria

Exclusion criteria: 1. Uncontrolled hypertension; 2. Active cardiovascular disease; 3. Liver disfunction; 4. Medication known to interfere with glucose metabolism (except for diabetic patients).

Design outcomes

Primary

Measure	Time frame
1. Ex vivo mitochondrial function; 2. In vivo mitochondrial function; 3. Insulin sensitivity; 4. Fat accumulation in muscle and heart; 5. Indirect calorimetry.	—

Secondary

Measure	Time frame
1. Plasma glucose; 2. Plasma insulin; 3. Plasma free fatty acids;	—

Contacts

Public ContactPatrick Schrauwen

Postbus 616 Department of Human Biology Maastricht University Medical Center

p.schrauwen@hb.unimaas.nl+31(0)43-388 15 02

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)