Minimally invasive esophagectomy esophageal cancer lung protective ventilation small tidal volume ventilation minimaal invasieve oesophagus resectie oesofaguscarcinoom longproectief beademen kleine teug volumina beademing
Conditions
Interventions
to use small tidal volumes during one lung ventilation
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Patients planned for elective minimally invasive esophagectomy for esophageal cancer after chemoradiation therapy
Exclusion criteria
Exclusion criteria: • Age 40 kg/m2 • Chronic obstructive pulmonary disease with a FEV1 of less than 65% • Preoperative systemic corticosteroid therapy • Severe cardiac disease (New York Heart Association class III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmia’s) • Altered liver function (Child-Pugh class B or more) • Neuromuscular disease (any) • Suspected acute pulmonary infection: In case patient receives antibiotics and meets at least one of the following criteria: new or changed sputum, new or changed lung opacities on chest X–ray when clinically indicated, tympanic temperature > 38.30C, WBC count > 12,000/mm3 • Consented for another interventional study or refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoints of this study are markers of pulmonary inflammation and coagulation, including cytokines and chemokines, neutrophil influx, markers of apoptosis, and markers of coagulation and fibrinolysis in lavage fluids obtained at the beginning and at the end of surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Duration of postoperative mechanical ventilation • Length of stay in intensive care unit and hospital • Incidence of postoperative pulmonary complications • Intraoperative hypoxemia • Anastomotic leakage • Mortality | — |
Contacts
Public ContactM.C.E. Woude, van der
Department of Intensive Care Medicine Atrium Medical Center Parkstad Henri Dunantstraat 5
Outcome results
None listed