Trans parenteral nutrition nutirtion Insulin resistance
Conditions
Interventions
Hyperinsulinemic euglycemic clamp with stable isotopes and concomitant infusion of a fish oil containing lipid emulsion, SMOFlipid®, on one occasion, and control saline infusion on the other occasion.
Sponsors
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male; 2. BMI 20-25 kg/m2; 3. Stable weight during 3 months before participation and during participation; 4. Normal physical activity with at most 2 times per week sport activities; 5. Age 18-30; 6. Non-smoking; 7. Caucasian.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to fish-, egg-, soya- or peanut protein; 2. Any medical condition or use of medication; 3. DM type II in first degree relatives; 4. Participation in other medical trial during the last 3 months.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| To study the accumulation of FA metabolites and components of the insulin signaling pathway after infusion of SMOFlipid®. | — |
Primary
| Measure | Time frame |
|---|---|
| To study the acute effect of iv SMOFlipid® on peripheral glucose uptake in healthy humans. | — |
Contacts
Public ContactM. Brands
Academic Medical Center (AMC) F5-162 Endocrinology and Metabolism
Outcome results
None listed