Type 2 diabetes (T2DM), Insulin resistance, Non-Alcoholic Fatty Liver Disease (NAFLD) Type 2 diabetes, insuline resisstentie en leververvetting
Conditions
Interventions
Both groups, the control group and the experimental group, will start with 3 weeks on a low-fat diet which will deliver 15 Energy% of energy as protein, 65 En% as CHO and 20 En% as fat. After these 3w
Sponsors
School for Nutrition, Toxicology and Metabolism of Maastricht University Medical centre + (MUMC+)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male sex; 2. Age 40-65 years; 3. BMI 25-35 kg/m2; 4. Sedentary; 5. Stable dietary habits; 6. Healthy.
Exclusion criteria
Exclusion criteria: 1. Current use of medication that is known to interfere with the results of the study; 2. Consuming more than 20 g of alcohol per day (± 2 units); 3. Serum-γ-glutamyltranspeptidase level > 70 IU/L; 4. A history of cardiovascular disease like congestive heart failure or acute myocardial infarction; 5. Plasma triacylglycerol > 4.5 mmol/L; 6. Familial hypercholesterolemia; 7. A history of liver disease; 8. Unstable body weight (weight gain or loss > 3 kg in the past three months); 9. Abuse of drugs; 10. Participation in another biomedical study within 1 month prior to the screening visit; 11. Impossible or difficult venipuncture during screening; 12. A fasting glucose above 7.0 mmol/L (13); 13. A contraindication to MRI scanning. These contraindications include patients with the following devices: a. Central nervous system aneurysm clips; b. Implanted neural stimulator; c. Implanted cardiac pacemaker or defibrillator; d. Cochlear implant; e. Ocular foreign body (e.g. metal shavings); f. Insulin pump; g. Metal shrapnel or bullet; h. Or metal containing corpora aliena in the eye of brains.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter is the difference in lipid accumulation and insulin sensitivity after a switch from a low-fat diet to a high-fat diet compared to the control group, which stays on a low-fat diet. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints differences the time-course of lipid accumulation and the relationship between the tissue parameter lipid ccumulation and the functional outcome parameter insulin resistance are considered. | — |
Contacts
Public ContactPatrick Schrauwen
Postbus 616 Department of Human Biology Maastricht University Medical Center
Outcome results
None listed