Upper respiratory tract infections (URTI) Gastrointestinal tract infections (GITI)
Conditions
Interventions
GUM A: containing intact active proteins, milk fat, and a prebiotic
GUM B: containing only intact active proteins
GUM C: containing a prebiotic
GUM REF: commercial available growing up milk
Sponsors
Chinese University of Hong Kong
Eligibility
Inclusion criteria
Inclusion criteria: - Apperently healthy - Between 1 and 2.5 years of age at inclusion, with a preference of 1-1.5 years - Boys and Girls of Chinese origin, living in Hong Kong - Able and willing to drink 400 ml milk per day (2 servings of 200 ml each) - Singned informed consent
Exclusion criteria
Exclusion criteria: - Underweight, wasting, or stunting (according to WHO criteria) - Clinically significant congenital diseases - In sick condition within two weeks prior to screening visit - Receive antibiotics, anti-viral drugs, montelukast, laxatives, or anti-diarrhoeal drug within 1 month before intervention starts - Any breastfeeding within last 2 months before intervention starts - Suspected tuberculosis by clinical or radiological examination or from history of contact with index patient with confirmed tuberculosis - Cow's milk allergy - History of severe allergic diseases (mild eczema of mild asthma is NOT excluded if unrelated to cow's milk allergy) - Usage of systemic immunosuppressive drugs within 3 months prior to screening visit (incidental use of topical, inhalational and intranasal corticosteroids are allowed) - Received rotavaccin ever - Received influenze vaccin within 12 months prior to recruitment - History of lactose intolerance - Siblings of already recruited children that are living in the same household with the exception of twins that can be allocated to the same group - Participation in another clinical trial at the same time or within 2 months prior to intervention starts - Children from mothers or caregivers whoare illiterate or unable to read and write Chinese - Premature (<37 weeks of gestation) at birth - No full committment of parents to omit dairy drinks from the child's diet during the study and replace these by the supplied growing up milk 4-apr-2016: One criterion on siblings changed into “Siblings of already recruited children that are living in the same household with the exception of twins that can be allocated to the same group. Recruitment of younger sibling of a subject (older sibling) from the same household is allowed provided that the subject (older sibling) has ended his/her participation in this study and the family returned unused GUM to the study site. The allocation of treatment group for the younger sibling will be independent of that for the older sibling.”
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Incidence of URTI (Upper respiratory tract infections) - Duration of GITI (Gastrointestinal tract infections) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Duration of URTI - Incidence of GITI - Nutritional status | — |
Contacts
Public ContactI. Bovee
Senior Nutritional Study Expert at FrieslandCampina
Outcome results
None listed