Genetic immunological causes of recurrent miscarriages; 'HLA sharing as a cause of recurrent miscarriages'.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON19918

Enrollment

432

Registered

2012-04-18

Start date

2012-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent miscarriages

Interventions

Peripheral bloodsamples from patient and partner will be obtained only once, also after informed consent buccal swabs from their children will be taken.

Eligibility

Inclusion criteria

Inclusion criteria: Recurrent miscarriages (>2 and < 20 weeks) and age < 36 years.

Exclusion criteria

Exclusion criteria: Parental chromosomal abnormalities and uterus anomalies.

Design outcomes

Primary

Measure	Time frame
Difference genetic profile patients and controls (HLA (mis)matches, frequency HLA-C2, frequency KIRAA, polymorphism hPR, mutations of complement regulatory proteins).	—

Secondary

Measure	Time frame
Pregnancy outcome.	—

Contacts

Public ContactK.W.M. Bloemenkamp

PO Box 9600

k.w.m.bloemenkamp@lumc.nl+31 (0)71 5263360

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)