Generally healthy elderly
Conditions
Interventions
1. Duration of intervention: 8 hours
2. Intervention group: 8 hours
3. Control group: 8 hours.
Sponsors
Danone Research – Centre for Specialised Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. Generally healthy male or female; 2. Ability to walk, sit down, and stand up independently; 3. Age 60 years or older; 4. BMI between 21 and 30 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Co-morbidities: A. Any (history of) gastrointestinal disease that interferes with GI function; B. Diagnosed and active treatment of Diabetes Mellitus type I or II; C. History of congestive heart failure, or recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery), or myocardial infarction in the past year. 2. Infection or fever in the last 7 days; 3. Medication: A. Use of antibiotics within 3 weeks prior to the study visit; B. Current use of corticosteroids, growth hormone, or testosterone. 4. Dietary or life style characteristics: A. Adherence to a weight loss diet; B. Use of protein containing or amino acid containing nutritional supplements within one week of study entry; C. Current participation in muscle strengthening program. 5. Contraindications to biopsy procedure: A. Platelet count (PLT) < 100,000; B. History of hypo- or hyper-coagulation disorders including use of a coumarin derivative, history of deep venous thrombosis (DVT), or pulmonary embolism (PE) at any point in lifetime; C. Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication); D. Allergy to local anaesthetic. 6. Blood hemoglobin < 9.0 g/dL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle protein synthesis rate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma amino acids, insulin, and glucose levels. | — |
Contacts
Public ContactR. Memelink
Outcome results
None listed