Non-small cell lung cancer.
Conditions
Interventions
1. Baseline CT perfusion scan
2. 50 mg sildenafil
3. 1 hour later: CT perfusion scan.
In addition to CT perfusion scans we will perform H2O PET scans to
assess tumor perfusion. The PET scans will be performed at baseline and
60 minutes after sildena
Sponsors
Prof. Dr. E.F. Smit
ef.smit@vumc.nl
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age > 18 years; 2. WHO performance status 0-1; 3. Adequate hematological, renal and hepatic functions: a. total bilirubin < 1.5 x UNL; b. ASAT/ALAT < 2 x UNL; c. alkaline phosphatase < 5 x UNL; d. creatinine < 130 mmol/L; 4. Primary tumour size ¡Ý1cm; 5. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Concurrent NTG, ritonivir, azoles, other P450 inhibitors; 2. Concurrent anti-hypertensive or nitrate medications; 3. Hypersensitivity to sildenafil/component of formulation; 4. Contrast allergy; 5. Hypotension <90/50mmg; 6. Other serious diseases such as heart failure, unstable angina, MI/CVA/serious arrhythmia within 6 months, diabetes; 7. History of visual loss and genetic degenerative retinal disease e.g. retinitis pigmentosa; 8. Pregnancy/lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumour perfusion change after sildenafil. | — |
Contacts
Public ContactJoline Lind
VU university medical centre Department of pulmonary diseases PO Box 7057
Outcome results
None listed