Psoriatic arthritis (PsA)
Conditions
Interventions
Sponsors
Reade, outpatient rheumatology clinic
Eligibility
Inclusion criteria
Inclusion criteria: - Adult (≥18 years) patients with active PsA - Indication to start with apremilast (Otezla)
Exclusion criteria
Exclusion criteria: - Inability or unwillingness to sign informed consent - Contraindication for apremilast (i.e. pregnancy and hypersensitivity to apremilast and/or its excipients)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Body composition =: this will be assessed using whole body DEXA, and body composition will be analyzed for whole-body and segmental lean soft tissue, fat mass and body fat percentage using DXA. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Height, weight, blood pressure, heart rate, abdominal wall and hip circumference - Presence of peripheral arthritis will be assessed by performing a 68 tender joint count and 66 swollen joint count - Patient pain, as reported on a visual analogue scale - Patient global assessment of disease activity as reported on a visual analogue scale - PASI - LEI - RAPID questionnaire - Laboratory investigations - Carotid intima media thickness (cIMT) - Dual energy CT-scanning (DECT-scan), at baseline and week 26, to determine the presence of atherosclerosis and plaque composition in large arteries | — |
Contacts
Public ContactM.T. Nurmohamed
Jan van Breemen Research Institute | Reade Postbus 58271
Outcome results
None listed