Parkinson Disease
Conditions
Keywords
Cognitive-motor training, Gait adaptability, Executive function, Electroencephalography
Brief summary
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands. Training that involves stopping or changing a movement may help people with Parkinson's disease respond to changing situations. These abilities may also support walking in challenging environments, such as stepping over obstacles. However, the effects of this type of training on cognitive function, walking performance, and brain activity remain unclear. Therefore, this study aims to compare the effects of cognitive-motor co-dependent training with conventional exercise training on these outcomes in people with Parkinson's disease.
Interventions
Cognitive-motor training is that cognitive tasks incorporated into motor tasks.
OTHERConventional physiotherapy
Conventional physiotherapy includes ROM exercise, stretching, strengthening exercise, and eye-hand coordination.
Sponsors
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* A clinical diagnosis of idiopathic Parkinson's disease * Stable use of prescribed antiparkinsonian medication for at least two weeks * Modified Hoehn and Yahr stage I to III * Age between 18 and 80 years * Ability to ambulate independently for at least 30 meters without assistive devices * A Mini-Mental State Examination (MMSE) score of ≥ 24 * Corrected vision and hearing sufficient to effectively receive external stimuli
Exclusion criteria
* The presence of any neurological, musculoskeletal, or cardiovascular disorders that could affect participation in this study * The presence of psychiatric disorders that could interfere with the ability to follow instructions or comply with study procedures * A history of brain surgery, such as deep brain stimulation (DBS)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gait speed | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Gait speed during obstacle crossing was measured using the GAITRite system. Continuous obstacle-crossing walking performance was assessed using the GaitUp system. |
| Step length | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure step length |
| Step width | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure step width |
| Single support time | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using GAITRite system to measure single support time |
| Gait Variability | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Gait variability during continuous obstacle crossing will be assessed using the GaitUp system and expressed as the coefficient of variation (CV = standard deviation / mean × 100%) of step time and stride length. |
| Stride length | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using the GaitUp system to measure stride length during continuous obstacle-crossing walking. |
| Swing phase | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Using the GaitUp system to measure swing phase during continuous obstacle-crossing walking. |
| Four Square Step Test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | The Four Square Step Test is a test used to assess the ability to step over objects and measures the time in seconds to navigate all four squares. |
| Event-related potential - N2 | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Measure event-related potential through electroencephalography during the Go/No-go test |
| Event-related potential - P300 | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Measure event-related potential through electroencephalography during the Go/No-go test |
| Stroop color and word test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Record numbers of corrected color words which the subject responds within 45 sec. |
| Trail making test | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Trail making test contain part A and part B. Faster completing the test indicates better executive function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Motor symptoms will be assessed using Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Scores range from 0 to 132, with higher scores indicating greater motor impairment. |
| Single-Leg Standing Balance | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Balance will be assessed by measuring the time, in seconds, that participants can stand on one leg. Longer standing times indicate better balance. |
| Montreal Cognitive Assessment | Before and after 8 weeks of intervention, as well as 4 weeks after intervention | Montreal Cognitive Assessment ranges from 0 to 30. Higher scores reflect better cognitive performances. |
Countries
Taiwan
Contacts
CONTACTYea-Ru Yang, PhD
Outcome results
None listed