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Comparative Study of The Efficacy and Safety of Subcision Combined With Injection of Exosomes Versus Subcision Alone in Treatment of Atrophic Post- Acne Scars.

Comparative Study of The Efficacy and Safety of Combined Subcision With Exosomes Injection Versus Subcision Alone in Treatment of Atrophic Post- Acne Scars

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07906509
Enrollment
20
Registered
2026-10-30
Start date
2024-05-15
Completion date
2026-02-12
Last updated
2026-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Scars - Atrophic

Brief summary

This split-face comparative prospective study was carried out on 20 patients presenting with atrophic post-acne scars. All participants were subjected to full history taking, general and dermatological examination, photographing before, during and after the end of the treatment. On the right side, combined subcision with exosomes injection was performed, whereas subcision alone was performed on the left side. Three treatment sessions were administered at 4-week intervals, followed by monthly follow-up for 3 months. Before the treatment sessions, patients were instructed to put topical anesthetic cream. During sessions, the treated areas were disinfected by alcohol 70%,1 ml of lidocaine Hcl 2% was administered into the treatment site at the subdermal level, subcision was done on both sides followed by 1 ml of intralesional exosome injection on the right side only. After sessions, patients were advised to put topical antibiotic twice daily for one week. In addition, patients advised to take systemic antibiotic therapy twice daily for one week.

Interventions

PROCEDURESubcision plus exosome injection

Three treatment sessions at monthly interval

PROCEDURESubcision

Three treatment sessions at monthly interval

Sponsors

Tanta University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Split-face ( right- left) comparative study

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

* patients with atrophic acne scars with bilateral and nearly symmetrical presentation who agree to be enrolled in the study

Exclusion criteria

* active acne History of keloids Bleeding and coagulation disorders

Design outcomes

Primary

MeasureTime frameDescription
Quartile grading scaleAfter 3 months from the last treatment sessionTwo blinded dermatologists will compare the photos of patients before and after treatment

Secondary

MeasureTime frame
Goodman and Baron scaleBefore and after 3 months from the last treatment session
Ultrasonic evaluation of skin thicknessBefore and after 3 months of treatment

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Oct 31, 2026