Acne Scars - Atrophic
Conditions
Brief summary
This split-face comparative prospective study was carried out on 20 patients presenting with atrophic post-acne scars. All participants were subjected to full history taking, general and dermatological examination, photographing before, during and after the end of the treatment. On the right side, combined subcision with exosomes injection was performed, whereas subcision alone was performed on the left side. Three treatment sessions were administered at 4-week intervals, followed by monthly follow-up for 3 months. Before the treatment sessions, patients were instructed to put topical anesthetic cream. During sessions, the treated areas were disinfected by alcohol 70%,1 ml of lidocaine Hcl 2% was administered into the treatment site at the subdermal level, subcision was done on both sides followed by 1 ml of intralesional exosome injection on the right side only. After sessions, patients were advised to put topical antibiotic twice daily for one week. In addition, patients advised to take systemic antibiotic therapy twice daily for one week.
Interventions
Three treatment sessions at monthly interval
Three treatment sessions at monthly interval
Sponsors
Study design
Intervention model description
Split-face ( right- left) comparative study
Eligibility
Inclusion criteria
* patients with atrophic acne scars with bilateral and nearly symmetrical presentation who agree to be enrolled in the study
Exclusion criteria
* active acne History of keloids Bleeding and coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quartile grading scale | After 3 months from the last treatment session | Two blinded dermatologists will compare the photos of patients before and after treatment |
Secondary
| Measure | Time frame |
|---|---|
| Goodman and Baron scale | Before and after 3 months from the last treatment session |
| Ultrasonic evaluation of skin thickness | Before and after 3 months of treatment |
Countries
Egypt