Wound Healing After Tooth Extraction
Conditions
Brief summary
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.
Interventions
DRUGCross-linked sodium hyaluronate 1%
Cross-linked sodium hyaluronate 1% applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
DEVICENon-cross-linked low-molecular-weight hyaluronic acid
Non-cross-linked low-molecular-weight hyaluronic acid applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
DEVICEGelatin sponge
Gelatin sponge placed in the extraction socket without hyaluronic acid after non-surgical tooth extraction.
Sponsors
Cyprus Health and Social Sciences University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-45 years * Systemically healthy * Light smokers, instructed to abstain completely from smoking for the first 72 postoperative hours * Requiring simple posterior tooth extraction * Clinically achievable hemostasis
Exclusion criteria
* Systemic diseases affecting healing * Pregnancy or lactation * Acute infection at the extraction site * Use of anti-inflammatory or immunosuppressive drugs * Surgical extraction requiring flap elevation or bone removal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ercentage Reduction in Wound Area | Postoperative days 0, 3, 7, and 14 | Wound area will be measured from standardized, calibrated clinical photographs using ImageJ. Percentage reduction will be calculated relative to baseline: \[(baseline wound area - follow-up wound area) / baseline wound area\] × 100. Results will be compared among the three groups over time. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wound Healing Score (WHS) | Postoperative days 3, 7, and 14 | Clinical wound healing will be assessed using the study's WHS, with a total score ranging from 0 to 9. |
| Index of Postoperative Recovery (IPR) | Postoperative days 3, 7, and 14 | Postoperative recovery will be assessed using the IPR measure specified in the study protocol. |
| Postoperative Pain Intensity | Postoperative days 1, 3, and 7 | Pain intensity will be recorded using a 10-cm visual analogue scale (VAS), where 0 indicates no pain and 10 indicates the worst pain. |
| Postoperative Analgesic Consumption | Postoperative days 1-7 | The number of analgesic doses taken by each participant will be recorded in the postoperative medication log. |
Countries
Cyprus
Contacts
CONTACTOmran Abdulwahab Nasab, ph.d
Outcome results
None listed