Wisdom Tooth Removal, Antibiotic Prophylaxis, Single Dose
Conditions
Keywords
Single dose Antibiotic Prophylaxis, Amoxicillin, Clindamycin, Azithromycin, Comparison, Third Molar Extraction
Brief summary
The goal of this clinical trial is to learn which drug amongst Amoxicillin, Clindamycin and Azithromycin single dose works better in reducing post-surgical complications in Participants getting lower wisdom teeth pulled. The main question it aims to answer is: • Which single dose drug lowers the post-surgical complications in participants of this study? Researcher will compare three single dose drugs (the administration of the complete amount of an antibiotic medication in one single administration to cure or prevent an infection). Participants will: * Take provided drug one hour before the treatment * Visit the OPD for Reading measurements same day before the surgery, same day after the surgery and third day after the surgery.
Detailed description
In this Clinical Trial, Principal Investigator is comparing three single dose antibiotic drugs by comparing post-operative outcomes of Lower third molar extraction (Wisdom Tooth getting pulled). After checking for Participant's eligibility. Participants will be asked for their consent to be part of research and then Initial Baseline reading will be measured and then they will be given medication and will be asked to take it and wait for an hour. After Surgery, once participant is calmed down Investigators will wait for 25-30mins and will record 2nd set of readings to check the effect of surgery on pain, mouth opening, bleeding. After Surgery day 3 participant will be called for follow-up that's when third set of readings will be measured. Post Data Collection Data Analysis will be done using SPSS 21
Interventions
Sponsors
Dow University of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals with no history antibiotics for past 1 month * No active infection going * No allergies to any antibiotics, analgesics, local anesthetic * Cases of low to medium difficulty * Age bracket from 18 years or older
Exclusion criteria
* Pregnant women * Lactating mothers * People who have any soft tissue healing disorder * Patient undergone radiotherapy * Patient having kidney or liver disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| No. of Participants with Dry Socket | from baseline pre-surgery to third day post-surgery | Alveolar Osteitis, sharp pain accompanied by smell and absence of blood clot. Reported as yes or no |
| No. of Participants with Surgical Site Infection | from baseline pre-surgery to third day post-surgery | Surgical Site infection presence of post-operative granulation tissue or non-healing, reported as yes or no |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| No. of Participants with Trismus | from baseline pre-surgery to third day post-surgery | Inability to open jaw till normal mouth opening range |
| Mean and Standard Deviation of Pain Score | from baseline pre-surgery to third day post-surgery | Pain Score measured on Likert scale. Where low score means less pain and higher score means more pain. |
| No. of Participants with Bleeding | from baseline pre-surgery to third day post-surgery | Presence and absence of Bleeding |
Contacts
CONTACTMeer M Fawad, Masters of Science
PRINCIPAL_INVESTIGATORMeer M Fawad, Masters of Science
Down University of Health Sciences
Outcome results
None listed