Skip to content

A Study of Treatment Delivery Preference In People With Kidney Cancer

Subcutaneous Versus Intravenous Immune Checkpoint Inhibitors, Treatment Burden, and Care Delivery for Patients With Renal Cell Carcinoma

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07872553
Enrollment
40
Registered
2026-10-13
Start date
2026-09-24
Completion date
2030-09-24
Last updated
2026-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Cell Carcinoma, Kidney Cancer

Keywords

Renal Cell Carcinoma, Kidney Cancer, Memorial Sloan Kettering Cancer Center, 26-208

Brief summary

The purpose of this study is to see if people prefer immunotherapy treatment for kidney cancer delivered intravenously or subcutaneously and if it is practical for participants to receive labs at home and have a video (telehealth) visit with their doctor prior to their day of treatment.

Interventions

Participants will be randomized to receive nivolumab subcutaneously

DRUGNivolumab

Participants will be randomized to receive Nivolumab intravenously

DRUGPembrolizumab injection

Participants will be randomized to receive Pembrolizumab subcutaneously

DRUGPembrolizumab

Participants will be randomized to receive Pembrolizumab intravenously

Sponsors

Memorial Sloan Kettering Cancer Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients: A patient cannot be considered eligible for this study unless ALL of the following conditions are met. * Patient is receiving standard of care treatment for renal cell carcinoma for one of the following indications: 1) NIVO monotherapy as maintenance, after ipilimumab and NIVO induction (up to 4 doses), 2) NIVO monotherapy as single-agent treatment, OR 3) adjuvant PEMBRO monotherapy or combination therapy with belzutifan. Of note, patient does not need to be newly initiating treatment to be eligible for this study. * For patients on NIVO monotherapy or PEMBRO (Groups 2 and 3 above), they must have received at least 1 dose as a standard of care to be eligible * Patient has at least 6 doses of planned treatment left as standard of care that can be given on protocol (either NIVO or PEMBRO) * For example, standard of care for adjuvant PEMBRO is 1 year of therapy which can be given at 3 (17 doses) or 6 (9 doses) week intervals. Patients can enter this trial after starting treatment but must have at least 6 doses of treatment left to be eligible. * For example, standard of care for maintenance NIVO (after ipilimumab + NIVO) is typically about 2 years of therapy. NIVO can be given at 2 (about 52 doses) or 4 week (about 26 doses) intervals. * Age ≥ 18 * Ability to speak and read English because we do not have the resources to translate all materials into other languages * Patient must be able to provide written informed consent, or a legal authorized representative (LAR)/caregiver must be identified to provide consent in cases where the patient cannot. * Patients are unable to receive investigational agents on other clinical trial protocols Providers (Medical Oncologists): * Medical oncologists in the genitourinary medical oncology department will be involved with this study if they are the treating investigator for patients who consent to this study * The medical oncologists who are involved in this will be asked to complete surveys

Design outcomes

Primary

MeasureTime frameDescription
Part I: Participants preference between intravenous/IV vs subcutaneous/SC immune checkpoint inhibitor (NIVO and PEMBRO) for Renal Cell Carcinoma.1 yearThe primary outcome is participants preference between the two formulations.
Part 2: Participant Preference between Standard of Care Delivery vs Labs at Home +Telehealth Visit1 yearThe primary outcome is participant preference between the two delivery models.

Countries

United States

Contacts

CONTACTSahil Doshi, MD
doshis@mskcc.org646-422-4341
CONTACTThomas Atkinson, PhD
atkinsot@mskcc.org646-888-0089
PRINCIPAL_INVESTIGATORSahil Doshi, MD

Memorial Sloan Kettering Cancer Center

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Oct 17, 2026