Knee Osteoarthritis, Oxidative Stress
Conditions
Brief summary
A six week patient study that intends to prove that training helps improve the life of people with osteoatritis of the knee. It looks at pain and function in daily life and markers in the blood that show stress at a cell level.
Detailed description
In this study you will be part of a group one that receives 6 weeks of training (2 sessions per week) or you are part of group two that will exercise by walking 6000 steps per day. To investigate the effect of the training and walking, there will be an first screening of your capillary blood (by use of a few drops of blood from your finger), and you will be asked to fill in some questionnaires about your symptoms, that will include a painscore and a questionair on your specific complaints. These test will be retaken at the end of your 6 weeks of training. The study is focussed to benefit you by strengthening the muscles around your knee and improving your overall fitness.
Interventions
OTHERsupervised training
supervised training by a trained physical therapist, focussed on strength and overall fitness
OTHERdaily walking
walking 6000 steps per day unsupervised
Sponsors
Mariette Boshuis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
randomised 2 group study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* diagnosed Knee osteoartritis in one or both knees
Exclusion criteria
* not able to walk 6000 steps * not able to participate in the training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NRPS Pain score | 6 weeks | numeric pain rating scale |
| PSPF | 6 weeks | Patient Specific Functional Scale |
| oxidative stress bloodmarkers | 6 weeks | d-Roms fast test |
Countries
Netherlands
Contacts
CONTACTMariette boshuis-scheenstra
CONTACTboudewijn Scheenstra
PRINCIPAL_INVESTIGATORAldo Scafoglieri, Prof
professor at VUB
Outcome results
None listed