Application Study of Individualized Mechanical Power Titration Strategy Based on PiCCO (Pulse Index Continuous Cardiac Output) Monitoring Parameters in ARDS Patients

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07839234

Enrollment

130

Registered

2026-09-24

Start date

2025-11-04

Completion date

2028-09-30

Last updated

2026-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome

Keywords

Acute respiratory distress syndrome, PiCCO, mechanical power

Brief summary

Based on PiCCO combined with MP, the optimal mechanical power setting of the ventilator for ARDS patients in normal supine/prone position is determined to reduce the damage to lung function during mechanical ventilation. By detecting peripheral serum NLRP3 and related inflammatory markers in ARDS patients, the relationship between NLRP3 and lung injury caused by mechanical ventilation was studied.

Interventions

OTHERProne position ventilation

Judgement of Prone Position Therapy Based on Oxygenation Index

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Admission to ICU * Accept mechanical ventilation, with an expected duration of more than 3 days * Diagnose 'ARDS' and meet the criteria for mild, moderate, and severe diagnosis * Age over 18 years old * Voluntarily participate in the study and sign an informed consent form (if the patient has consciousness disorders, it can be signed by a legal representative)

Exclusion criteria

: * There are contraindications for PiCCO monitoring * Pregnant or lactating women * Recently (within one month) participated in other interventional clinical studies * Expected death within 48 hours

Design outcomes

Primary

Measure	Time frame	Description
mechanical power	Data were obtained within the first hour post-intubation, at 8:00 AM (±1 h) daily for the subsequent three consecutive days, and during position changes (prone to supine or supine to prone) within these three days.	deep sedation, elimination of spontaneous breathing, measurement via ventilator.Mechanical power (MP) was calculated from the median ventilator parameters via the following equation: mechanical power (J/min) = 0.098× RR × Vt × (PIP - 0.5(Pplateau-PEEP)), where PIP =peak inspiratory pressure. The MP was normalized to the predicted body weight (norMP) = MP/PBW,where PBW was the predicted body weight measured in kilograms.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 25, 2026