Glucose Control
Conditions
Brief summary
This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\\le 120\\text{ mg/dL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\\text{ mg/dL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.
Interventions
OTHERHigh Intensity Interval Training
The Norwegian 4x4: The workout begins with a 5-to-10-minute warm-up, followed by four separate 4-minute high-intensity intervals where you push your body to 85%-95% of your maximum heart rate (roughly an 8 or 9 out of 10 effort level, where you are breathing too heavily to speak full sentences). Each intense "push" is interspersed with a 3-minute active recovery period of low-intensity movement-such as walking or light cycling-to let your heart rate drop back down to roughly 60%-70% of its maximum before starting the next round.
45 minutes of zone 2 training for five consecutive days
Sponsors
University of California, San Francisco
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Age 18 years or older. Non-diabetic or pre-diabetic status (defined by medical history or standard screening criteria, e.g., HbA1c \< 6.5%). Capable and willing to participate in both Zone 2 aerobic exercise and high-intensity interval training (HIIT) protocols. Willing to wear a continuous glucose monitor (Dexcom G7) continuously for the 11-day study duration. Able to provide written informed consent.
Exclusion criteria
Diagnosis of Type 1 or Type 2 diabetes. Use of glucose-lowering medications, insulin, or other pharmaceuticals that significantly alter glucose metabolism. Current skin conditions, allergies, or sensitivities to medical-grade adhesives that prevent continuous glucose monitor placement. Musculoskeletal, cardiovascular, or neurological conditions that contraindicate vigorous exercise or high-intensity interval training. Pregnant or planning to become pregnant during the study period. Concurrent participation in another clinical trial or interventional exercise study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Glucose Concentration | Measured continuously over each 5-day exercise/recovery block within the 11-day monitoring period. | Average glucose level recorded by continuous glucose monitor (CGM) across the exercise intervention block and its subsequent recovery window. |
| Time in Range (TIR) | Measured continuously over each 5-day exercise/recovery block within the 11-day monitoring period. | Percentage of time spent with sensor glucose values under 120mg/dL during the active exercise block and its recovery window. |
Countries
United States
Contacts
CONTACTJeanne Noble, MD
PRINCIPAL_INVESTIGATORJeanne Noble, MD
University of California, San Francisco
Outcome results
None listed