Osteopenia
Conditions
Brief summary
The purpose of this study is to learn whether combining time-restricted eating with supervised resistance exercise can improve bone health in adults with osteopenia.
Interventions
BEHAVIORALTime-restricted eating combined with resistance exercise (TRE+Ex)
Participants in the TRE+Ex group will be asked to fast for a target of 16 hours per day, consuming food ad libitum within an 8-hour eating window beginning between 6:30 and 9:30 AM, 6 days per week for 12 weeks. They will also complete supervised progressive resistance exercise training 3 days per week.
BEHAVIORALHabitual eating pattern combined with resistance exercise (HE+Ex)
Participants in the HE+Ex group will be instructed to maintain their habitual eating patterns and complete supervised progressive resistance exercise training 3 days per week.
Sponsors
University of Alabama at Birmingham
UAB Center for Exercise Medicine
UAB Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Men and women aged 50-75 years with body mass index (BMI) \>25kg/m2 * Osteopenia, defined as a T score between -1.0 and -2.5 at the lumbar spine, femoral neck, or total hip * Elevated adiposity, defined by waist circumference \>102 cm in men or \>88 cm in women * Stable health history over the past 2 months * Stable medication history over the past 2 months, as recommended by the primary provider * Willing and able to provide informed consent
Exclusion criteria
* Participation in a formal weight loss program, intentional caloric restriction, fasting \>10 hours/day, or ≥10 pounds weight loss within the past 3 months * Current participation in structured exercise training, supervised rehabilitation, or \>150 minutes/week of moderate intensity physical activity * Medical conditions or use of medications affecting bone metabolism * Diagnosed diabetes or use of insulin or glucose lowering medications * Resting heart rate \>120 beats/minute or daytime blood pressure ≥180/100 mmHg * Unstable angina, myocardial infarction, or stroke within the past 3 months * Continuous supplemental oxygen use for chronic pulmonary disease or heart failure * Rheumatoid arthritis, Parkinson's disease, dialysis, active cancer treatment within the past year, or diagnosed cognitive impairment * Absolute contraindications to exercise training according to American College of Sports Medicine guidelines * Unable to fast for 16 hours * Any condition that in the opinion of the investigator would impair ability to participate in the trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone mineral density | Baseline and 12 weeks | measured by dual-energy X-ray absorptiometry |
| Bone mineral content | Baseline and 12 weeks | measured by dual-energy X-ray absorptiometry |
Countries
United States
Outcome results
None listed