Absenteeism, Diarrhea, Menstrual Hygiene, Respiratory Tract Infections (RTI)
Conditions
Keywords
water sanitation and hygiene, cluster randomised controlled trial, menstrual health, absenteeism, Uganda
Brief summary
Karamoja, in north-eastern Uganda, is among the most water-insecure regions in sub-Saharan Africa. Only 24 per cent of households can access the WHO-recommended 20 litres of water per person per day. Only 11.7 per cent have access to improved sanitation. A rapid vulnerability assessment covered all 182 operational primary schools in the sub-region between October and November 2025. It identified 53 schools as severely water insecure and a further 37 as moderately water insecure. Together, these schools serve an estimated 196,000 learners. The assessment also found that 89 schools lacked enough latrines to meet the national pupil-to-latrine ratio. Seventy-eight schools had no functional menstrual health management facilities. This study is a three-arm, phase-in cluster-randomised controlled trial. It evaluates the causal effects of a climate-resilient school WASH package on children's health and school attendance. It also examines adolescent girls' menstrual health self-efficacy. The study covers 60 primary schools that were found to be water-insecure across Karamoja's nine districts. The schools were stratified into three geographic zones. The researchers then used covariate-constrained randomisation to assign schools to three study arms. Phase 1 includes 30 schools receiving the intervention early. Phase 2 includes 20 schools receiving it later. The remaining 10 schools form the pure control group. The intervention combines climate-resilient WASH infrastructure with capacity-building and social and behaviour change activities. The infrastructure includes motorised boreholes, sex-disaggregated latrines and handwashing stations built to national standards. A subset of the boreholes will have data loggers for remote monitoring. The package also provides dedicated menstrual health facilities. These include enclosed changing areas and hygienic waste-disposal systems. Community water access points will be installed next to each school. Capacity-building activities will involve School Management Committees, Parent-Teacher Associations, teachers, District Water Officers and School Health Clubs. Data will be collected through three repeated cross-sectional rounds. The baseline will take place in the fourth quarter of 2026. The midline will take place in the first quarter of 2028, and the endline in the first quarter of 2030. Seven instruments will be used. These include pupil and matched caregiver surveys, school WASH facility and classroom roll-call observations, and head teacher and teacher surveys. The study will also digitise school enrolment, attendance and examination records. Community leaders will be interviewed separately. In each round, the sample will include 20 post-menarche girls and 20 general pupils per school. The study will interview one caregiver for each sampled pupil. The study will also interview six teachers, the head teacher and four community leaders in each school catchment. The study has three co-primary outcomes. The first is the pupil absence rate, measured using digitised attendance registers. The second is the seven-day prevalence of diarrhoea among pupils. The third is menstrual health self-efficacy among post-menarche girls. We will measure this using the 26-item Self-Efficacy in Addressing Menstrual Needs Scale (SAMNS-26). The primary analysis will estimate the intent-to-treat effect of assignment to Phase 1. At midline, Phase 1 schools will be compared with Phase 2 and pure control schools. We will conduct two comparisons at endline. First, we will compare all treated schools with the pure control group. Second, Phase 1 schools will be compared with Phase 2 schools to test whether effects differ by exposure duration.
Detailed description
BACKGROUND AND RATIONALE Access to safe water and sanitation in schools is essential for children's health, dignity and learning. However, evidence on the effects of school WASH interventions remains mixed. A systematic review of 38 studies found reductions in school absence ranging from 21 to 61 per cent. Several trials reported larger effects for girls. However, some cluster-randomised trials found no effects. These include a trial in 60 Ethiopian schools that found no improvement in attendance. The largest effects are generally found in settings with severe water scarcity. A Kenyan trial found a 58 per cent reduction in the odds of absence among girls in schools receiving water treatment. However, it found no overall effect across all schools. The intervention also reduced diarrhoea prevalence by 66 per cent in water-scarce schools. It had no effect in schools that already had access to water. A recent meta-analysis of 50 trials found a similar pattern. WASH interventions reduced diarrhoea risk by 33 per cent during the dry season, compared with 18 per cent during the rainy season. Evidence on menstrual health interventions is also mixed. In Uganda, girls are nearly six times more likely to miss school during menstruation than on other days. Multi-component menstrual health programmes consistently improve knowledge, attitudes and self-efficacy. However, the most rigorous Ugandan trial to date found no effects on school attendance or educational performance after one year. This was despite improvements across almost every measured dimension of menstrual health. This trial takes place in a setting with severe baseline deprivation. Existing evidence suggests that WASH interventions may have larger effects under such conditions. The trial therefore examines whether the intervention produces detectable health and education effects in Karamoja. SETTING AND CLUSTER SELECTION The trial covers all nine Karamoja districts. These are Abim, Amudat, Kaabong, Karenga, Kotido, Moroto, Nabilatuk, Nakapiripirit and Napak. A rapid vulnerability assessment was conducted between October and November 2025. It assessed all 182 operational primary schools using 12 water-security indicators. These indicators were adapted from the Household Water Insecurity Experiences Scale. We classified each school as water secure or as experiencing mild, moderate, or severe water insecurity. The 60 schools with the highest composite priority scores form the trial sample. Eligibility was also conditional on hydrological viability, as confirmed through groundwater surveys. The nine districts were grouped into three geographic zones. The groupings reflect Uganda's 1974 provincial zoning and Karamoja's agroecological gradient. The North zone includes Kaabong and Karenga and has 17 study schools. The Central zone includes Kotido, Abim and Nabilatuk and has 25 schools. The South zone includes Moroto, Napak, Nakapiripirit and Amudat and has 18 schools. RANDOMISATION Schools were allocated proportionally within each zone. This ensured that every zone contributed to all three study arms in proportion to its share of the sample. In the North, eight schools were assigned to Phase 1, six to Phase 2 and three to the pure control group. The corresponding allocation was 13, eight and four schools in the Central zone. In the South, we assigned nine schools to Phase 1, six to Phase 2, and three to the pure control group. The study used covariate-constrained randomisation. We generated 10,000 candidate allocations. Each candidate simultaneously assigned all 60 schools while maintaining the zone-level quotas. For each allocation, we calculated the Mahalanobis distance for every pair of study arms. The calculation considered all balancing covariates and accounted for correlations between them. We used the fifth percentile of the maximum Mahalanobis-distance distribution as the acceptance threshold. This produced about 500 well-balanced allocations. We then randomly selected one allocation from this set. Random selection from the acceptable set preserves the reference distribution required for valid permutation-based inference. We did not use the conventional chi-squared threshold. Preliminary analysis showed that it accepted all 10,000 candidate allocations and was therefore equivalent to simple randomisation. We used three covariates to assess balance. These were the HWISE water-insecurity score, the infrastructure vulnerability deficit score and the school enrolment score. We normalised each measure to a scale from zero to one. The standardised mean differences between Phase 1 and the pooled comparison group were -0.10 for water insecurity, -0.07 for infrastructure vulnerability and -0.24 for enrolment. We also examined several variables that were not used to constrain randomisation. These included proximity to a health facility, girls' share of enrolment, the pupil-teacher ratio and Primary Leaving Examination scores. These variables were closely balanced across the study arms. We use 0.25 as the reporting benchmark for individual standardised mean differences. This threshold is appropriate for a small trial with prespecified ANCOVA adjustment. Achieving differences below 0.10 across all variables was not considered feasible with only 10 pure control schools. Randomisation was completed before baseline data collection. This allowed implementing partners to scope the infrastructure requirements of Phase 1 schools and begin procurement. INTERVENTION Schools in Phase 1 and Phase 2 receive the same intervention package. The two arms differ only in implementation timing. Phase 1 schools begin receiving the intervention in 2026. Phase 2 schools begin after the midline survey in the first quarter of 2028. Pure control schools receive no intervention during the evaluation period. Infrastructure The intervention provides climate-resilient water systems, including motorised boreholes. Fifteen boreholes will have data loggers for remote monitoring of water levels and functionality. The intervention also constructs or rehabilitates sex-disaggregated latrines and handwashing stations. These facilities will meet national pupil-to-latrine standards. Dedicated menstrual health facilities will also be constructed. They will include enclosed changing areas, a water supply and hygienic waste-disposal systems. Community water access points will be installed next to participating schools. The package also includes groundwater monitoring, water-quality testing and surveillance. Capacity-building and social and behaviour change District Water Officers will receive training on school WASH monitoring and water-quality testing. School Management Committees and Parent-Teacher Associations will receive training on facility operation and maintenance. This will cover basic repairs, record-keeping and maintenance budgeting. Teachers and school prefects will receive training on menstrual hygiene management. The programme will establish and support School Health Clubs. It will also conduct community engagement and social and behaviour change activities. Schools and communities will receive information, education and communication materials. Selected participants will also be trained to produce menstrual health products locally. DESIGN AND MEASUREMENT The trial uses a repeated cross-sectional design. A new sample will be drawn from current enrolment records during each survey round. The study will not attempt to recontact pupils interviewed in earlier rounds. This design avoids attrition caused by grade progression and graduation. It also limits attrition associated with the high residential mobility of Karamoja's pastoral communities. The design estimates population-level effects within each school. It does not estimate changes within individual pupils over time. Each school-level sample will include 20 post-menarche girls aged approximately 11-17 years. It will also include 20 general pupils drawn from Primary 2 to Primary 7. Approximately two-thirds of the general pupil sample will be boys. Both groups will be selected systematically from school enrolment registers. Sampling will be proportional to enrolment across grades. Each sampled pupil will be matched to a parent or legal guardian. Caregivers will be interviewed separately from the pupils. We will randomly select six classroom teachers from each school's staff register. The head teacher will also be interviewed. The study will purposively select four community leaders from each school catchment. One structured WASH facility observation and one classroom roll call will be conducted in each school during every round. The study will also digitise school enrolment, attendance and examination registers. This will cover the full academic year preceding each survey. All quantitative data will be collected on tablets using SurveyCTO. The electronic instruments will include range and skip-logic checks. The instruments will be reviewed for contextual relevance before each survey round. They will then be translated into Ngakarimojong and back-translated. Trained female enumerators will administer all modules for post-menarche girls. Quality assurance will include daily high-frequency checks against prespecified range and logic rules. Supervisors will back-check approximately 10 per cent of completed interviews. Unannounced spot checks will also be conducted across all field teams. School records will be digitised through a two-part procedure during a single school visit. First, whole-school enrolment, attendance and examination registers will be photographed. The pupil name and identification columns will be physically covered before each photograph is taken. The photographs will therefore show only grade, age, sex, attendance marks and examination scores. These records will be de-identified and will not require individual parental consent. Second, we will transcribe individual register information for the approximately 40 pupils sampled in each school. This will apply only to pupils whose pupil-caregiver dyads completed the consent process and participated in the survey. We will link their register information to their study identification numbers. STATISTICAL POWER The power calculations assume 80 per cent power and a 5 per cent significance level. They consider intra-cluster correlations of 0.10 and 0.15. They also assume an R-squared of 25 per cent at the individual and school levels. At midline, Phase 1 will include 30 schools, and the pooled comparison group will include 30 schools. This comparison can detect standardised effects of approximately 0.20 to 0.23 in the full pupil sample. It can detect effects of approximately 0.22 to 0.25 among post-menarche girls. At endline, the comparison between all treated schools and pure control schools can detect effects of approximately 0.27 to 0.31 standard deviations. The larger minimum detectable effect reflects that most schools are allocated to treatment by that stage. The comparison between Phase 1 and Phase 2 can detect differential-exposure effects of approximately 0.22 to 0.26 standard deviations. Comparable WASH trials in the region have reported effects ranging from 0.17 to 0.52 standard deviations. The largest effects have generally been observed in settings with severe baseline water scarcity. ANALYSIS A detailed pre-analysis plan will specify all regression models, outcome definitions and subgroup analyses. We will register it before the first follow-up survey. The study will also conduct a prospective cost-effectiveness analysis. Programme expenditure will be coded by output and geographic scope at the transaction level. The analysis will report the cost per beneficiary reached and per unit of outcome achieved. ETHICS The study was approved by the Mildmay Uganda Research Ethics Committee on 3 September 2026 (REC-REF 2308-2026). The Uganda National Council for Science and Technology approved the study. Parents or legal guardians will provide written informed consent before any pupil interview. Pupils will then provide their own assent. Adult respondents will provide informed consent before participating. School administrators will provide permission for facility observations and access to school records. Interviews with minors will be conducted in semi-private locations away from the main school area. A designated member of school staff will remain within sight during each interview. For menstrual health modules, a female staff member will perform this role. She will remain far enough away to ensure that responses cannot be overheard. Study data will be recorded using study identification numbers. Direct personal identifiers will be stored separately in encrypted files. A child-protection referral protocol will guide responses to any disclosures requiring further action. Participants will receive in-kind compensation worth approximately UGX 3,000. This recognises their time without creating undue inducement. Policy equipoise exists regarding the intervention's educational effects. The theory of change predicts that reduced illness, better menstrual hygiene management and less time spent collecting water will improve attendance and educational achievement. However, evidence linking school WASH interventions to measurable educational gains remains limited and contested. The phase-in design follows the programme's existing implementation plan. The team determined this plan independently of the evaluation. No school has been delayed because of the evaluation design.
Interventions
Construction of climate-resilient water systems on school grounds, comprising motorised boreholes (15 fitted with data loggers for remote monitoring of functionality and water levels); construction or rehabilitation of sex-disaggregated latrines and handwashing stations to meet national pupil-to-latrine ratio standards; construction of dedicated menstrual health sanitary facilities with enclosed changing areas, water supply and hygienic waste disposal; construction of community water access points adjacent to each school extending water access to surrounding households; and groundwater monitoring, water quality testing and surveillance. The UNICEF Uganda Country Office contracts the works, and UNICEF engineers and district local governments jointly supervise them.
Training of District Water Officers on WASH-in-schools monitoring protocols and water quality testing; training of School Management Committees and Parent-Teacher Associations on operation and maintenance of WASH facilities including basic repair, record-keeping and maintenance budgeting; training of teachers and school prefects on menstrual hygiene management; formation or strengthening of School Health Clubs as a peer-to-peer platform for hygiene and menstrual health promotion; community engagement and social and behaviour change campaigns; provision of information, education and communication materials; and training on local manufacture of menstrual health products. Delivered through UNICEF implementing partners and embedded within district health and education systems.
Sponsors
Study design
Intervention model description
The study is a three-arm cluster-randomised trial with a phased roll-out. Schools are the unit of randomisation. Sixty government primary schools were randomised. Individual pupils, caregivers, teachers and head teachers are the units of observation and analysis. Standard errors will be clustered at the school level. Phase 1 comprises 30 schools and receives the intervention from mid-2026. Phase 2 comprises 20 schools and receives the same intervention after the midline survey in the first quarter of 2028. The remaining 10 schools form the pure control group. They receive no intervention during the evaluation period. We stratified randomisation by three geographic zones. We allocated arm quotas proportionally within each zone. We then used covariate-constrained randomisation based on three school-level covariates. We will collect data through three repeated cross-sectional rounds. We will draw a new independent sample from current enrolment registers in each round. The study will th
Eligibility
Inclusion criteria
CLUSTER LEVEL (school) * Government primary school, operational at the time of the October-November 2025 rapid vulnerability assessment, located in one of the nine districts of the Karamoja sub-region (Abim, Amudat, Kaabong, Karenga, Kotido, Moroto, Nabilatuk, Nakapiripirit, Napak) * Classified in the severe or acutely affected moderate water insecurity tier on the adapted HWISE assessment, and among the 60 highest composite priority scores across all 182 assessed schools * Hydrological viability confirmed: sub-surface geology and groundwater survey establish the feasibility of a viable water source at or adjacent to the school site * Head teacher and school administration grant permission for facility observation and school records capture INDIVIDUAL LEVEL Pupils: * Enrolled in grades P2 to P7 at a trial school and appearing on the current enrolment register at the time of sampling * Selected by systematic random sampling from the enrolment register with proportional representation across grades * Parent or legal guardian has provided written informed consent, and the pupil has provided assent * For the menstrual health sub-sample: post-menarche, approximately aged 11 to 17 Caregivers: * Parent or legal guardian of a sampled pupil, matched one-to-one * Provides own informed consent Teachers and head teachers: * Currently employed and appearing on the staff register of a trial school * Teachers selected by simple random sampling from the staff register, six per school * Provide their own informed consent Community leaders: * Local council chairperson, religious leader, women's group representative or community elder resident in the catchment area of a trial school * Provides own informed consent
Exclusion criteria
* Schools not confirmed hydrologically viable for a school-site water source * Schools outside the top 60 composite priority scores * Pupils not appearing on the current enrolment register at the time of sampling * Any individual for whom consent (and, for pupils, both guardian consent and pupil assent) is not obtained * Any individual who declines or withdraws at any point, without requirement to give a reason and without consequence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| School absence rate among enrolled pupils | Baseline (month 0), midline (month 15), endline (month 40) | Proportion of scheduled school days on which a pupil is recorded absent in the school's termly attendance registers for the full academic year preceding each survey round. Registers are digitised at each round by photographic capture with pupil name columns covered (whole-school, de-identified) and by transcription for the approximately 40 consented sampled pupils per school. Computed at pupil level and aggregated to school level, disaggregated by sex. Source: Module 6, School Records. Analysed as an intent-to-treat contrast of Phase 1 assignment against Phase 2 and pure control at midline, with school-clustered standard errors. |
| Seven-day period prevalence of diarrhoea among pupils | Baseline (month 0), midline (month 15), endline (month 40) | Proportion of sampled pupils reporting three or more loose or watery stools on any one day during the seven days preceding the interview, following the WHO IMCI case definition and the recall structure used in Freeman et al. 2012/2014 and Bick et al. 2024. Self-reported by the pupil in a private interview. Source: Module 1, Pupil Survey, item B2. A two-day recall measure (item B1) is retained as a lower-bias secondary measure of the same construct. |
| Self-efficacy in addressing menstrual needs (SAMNS-26) among post-menarche girls | Baseline (month 0), midline (month 15), endline (month 40) | Score on the Self-Efficacy in Addressing Menstrual Needs Scale (SAMNS-26; Hunter et al. 2022), administered to the sub-sample of 20 post-menarche girls aged approximately 11-17 per school by trained female enumerators. Twenty-six items, each prefixed "How sure are you that..." and scored on a 0-3 scale (0 = not at all sure, 3 = very sure). Subscale and total scores are computed as the item mean rescaled to 0-100. Three subscales are reported: menstrual hygiene preparation and maintenance, menstrual pain management, and engagement in stigmatised tasks. Higher scores indicate greater self-efficacy. Source: Module 1, Section O. |
Countries
Uganda
Contacts
Center for Evaluation and Development (C4ED)
Emory University
UNICEF
UNICEF