A Randomized Controlled Trial Evaluating the Efficacy of Soaking Endotracheal Tube in Dexamethasone Solution for Prevention of Postoperative Sore Throat After Laparoscopic Cholecystectomy

Topical Dexamethasone Tube Soaking for Prevention of Postoperative Sore Throat (POST) Following Endotracheal Intubation for Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07823192

Enrollment

Registered

2026-09-16

Start date

2026-11-01

Completion date

2027-03-01

Last updated

2026-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Sore Throat

Keywords

post operative sore throat, ETT soaking

Brief summary

The goal of this clinical trial is to learn if topical application of dexamethasone will prevent sore throat caused by endotracheal intubation in healthy patients undergoing elective surgery. The main question it aims to answer is: • Does soaking the endotracheal tube in steroid solution before intubation lower the incidence of postoperative sore throat? Researcher will compare dexamethasone-soaked endotracheal tube to placebo (normal saline-soaked endotracheal tube) to see if topical steroid application in this way reduces development of sore throat. Participants will be: * Intubated with an endotracheal tube, that was either soaked in normal saline or dexamethasone solution, at induction of general anesthesia prior to undergoing elective cholecystectomy * Interviewed by the researcher 24 hours after their surgery to assess if they experienced any throat soreness

Interventions

DRUGSteroid Drug

Endotracheal tube will be soaked in dexamethasone solution for 10 minutes prior to intubation

DRUGNormal (0.9%) saline

Endotracheal tube will be soaked in normal saline for 10 minutes prior to intubation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing general anesthesia requiring ETT insertion during elective laparoscopic cholecystectomy. * ASA I \& ASA II patients * Patients consenting to be a part of the study

Exclusion criteria

* Patients having diabetes mellitus * Patients with suspected or incidental difficult Intubation

Design outcomes

Primary

Measure	Time frame	Description
Incidence of post operative sore throat	Within 24 hours of surgery	Proportion of patients who develop sore throat after surgery

Countries

Pakistan

Contacts

CONTACTMariam Niaz, MBBS

dr.mariamniaz@gmail.com+923391715167

STUDY_CHAIRDr Ammar Ali Shah, MBBS DA FCPS MHPE Fellowship

KRL Hospital, Islamabad

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 17, 2026