Kidney Failure, Chronic, Quality of Life
Conditions
Keywords
Twice-weekly hemodialysis, Thrice-weekly hemodialysis, KDQOL-36, Residual kidney function, Quality of life
Brief summary
This prospective cohort study aims to compare clinical outcomes and health-related quality of life between adults receiving established twice-weekly versus thrice-weekly maintenance hemodialysis at Assiut University Hospitals.
Detailed description
Thrice-weekly maintenance hemodialysis is the conventional schedule. Twice-weekly hemodialysis is used selectively in patients with residual kidney function. Local prospective comparative data in Egypt are limited. This observational study will include adults with end-stage kidney disease receiving established twice-weekly or thrice-weekly in-center maintenance hemodialysis. Patients will be followed according to their prescribed schedule without research-driven changes. Health-related quality of life will be assessed using the Arabic KDQOL-36 at baseline, 3 months, and 6 months. Clinical outcomes including adequacy, residual kidney function, hospitalization, and mortality will be recorded.
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \- Age 18 years or older * Established end-stage kidney disease requiring maintenance hemodialysis * Receiving in-center maintenance hemodialysis at Assiut University Hospitals * On maintenance hemodialysis for at least one month before enrollment * Established twice-weekly or thrice-weekly schedule prescribed by the treating team * Clinically stable at recruitment * Able to understand and respond to the questionnaire * Written informed consent
Exclusion criteria
* \- Acute kidney injury without established end-stage kidney disease * Hemodialysis for less than one month * Peritoneal dialysis or kidney transplantation during follow-up * Acute severe illness requiring intensive care at recruitment * Severe cognitive, psychiatric or neurological impairment preventing reliable questionnaire responses * Active malignancy with expected survival too short to complete follow-up * Temporary dialysis solely for an acute indication * Refusal to participate * Permanent transfer to another dialysis center during follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Health-related quality of life score | At baseline, 3 months, and 6 months | Mean total score of the Arabic Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire. The KDQOL-36 score ranges from 0 to 100; higher scores indicate better health-related quality of life. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dialysis adequacy | Up to 6 months | Mean single-pool Kt/V (for thrice-weekly) or weekly Kt/V incorporating residual kidney clearance (for twice-weekly). |
| Residual urine output | Up to 6 months | Mean daily urine volume (mL/day) in patients with residual kidney function. |
| Hospitalization rate | Up to 6 months | Proportion of patients requiring hospital admission during follow-up. |
| Interdialytic weight gain | Up to 6 months | Mean interdialytic weight gain (kg). |
| Mortality | Up to 6 months | Proportion of patients who die during the follow-up period. |
Contacts
CONTACTJustin g shawky, Resident
STUDY_CHAIRmarwa k abdo, prof
Internal Medicine Department, Assiut University Hospitals
Outcome results
None listed