Predictors of Prolonged Mechanical Ventilation in Preterm Infants

Predictors of Prolonged Mechanical Ventilation in Preterm Infants Admitted to Neonatal Intensive Care Unit of Assiut University Children Hospital

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07821632

Enrollment

100

Registered

2026-09-16

Start date

2026-09-10

Completion date

2028-04-10

Last updated

2026-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary Dysplasia, Premature Birth, Respiration Failure

Keywords

Prolonged mechanical, ventilation, Preterm infants, NICU, Predictors, Extubation, Assiut

Brief summary

This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.

Detailed description

Prolonged mechanical ventilation in preterm infants is associated with increased morbidity including bronchopulmonary dysplasia and neurodevelopmental impairment. This prospective observational study will include preterm infants (born before 37 completed weeks) who require invasive mechanical ventilation. Infants will be classified into two groups according to the duration of invasive mechanical ventilation: prolonged (\>7 days or frequent reintubation) and non-prolonged (≤7 days). clinical, perinatal, and laboratory predictors of prolonged mechanical ventilation will be evaluated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 36 Weeks

Healthy volunteers

Inclusion criteria

* \- Preterm infants born before 37 completed weeks of gestation * Admission to the NICU within the neonatal period * Requirement for invasive mechanical ventilation * Written informed consent from parents or legal guardians

Exclusion criteria

* \- Infants born after 37 weeks of gestation * Major congenital anomalies * Chromosomal abnormalities * Congenital neuromuscular disorders * Cyanotic congenital heart disease

Design outcomes

Primary

Measure	Time frame	Description
Occurrence of prolonged mechanical ventilation	Up to 30 days	Proportion of preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation.

Secondary

Measure	Time frame	Description
Duration of invasive mechanical ventilation	Up to 30 days	Total number of days of invasive mechanical ventilation.
Successful extubation rate	Up to 30 days	Proportion of infants who are successfully extubated without re-intubation within 48-72 hours.
Incidence of bronchopulmonary dysplasia	Up to 30 days	Proportion of infants diagnosed with bronchopulmonary dysplasia.
Incidence of neonatal sepsis	Up to 30 days	Proportion of infants diagnosed with neonatal sepsis.
Duration of NICU stay	Up to 30 days	Length of stay in the neonatal intensive care unit in days.
In-hospital mortality	Up to 30 days	Proportion of infants who die before hospital discharge.

Contacts

CONTACTDemiana Y Zakaria, Resident

Demiana.16266368@med.aun.edu.eg0 1280798683

STUDY_CHAIRJaafar I Mohammed, prof

pediatrics Department, Assiut University Hospitals

Outcome results