Nail Diseases
Conditions
Brief summary
The purpose of this study is to directly compare the efficacy of suzetrigine vs. oxycodone+acetaminophen vs. alternating acetaminophen/ibuprofen in controlling post-operative pain after the following nail unit procedures.
Interventions
DRUGSuzetrigine
Participants will receive two 50 mg oral tablets on day 1, followed by 50 mg oral tablets every 12 hours for 5 days
DRUGOxycodone + Acetaminophen
Participants will receive Oxycodone + acetaminophen combination administered orally at a dose of 50 mg/325 mg per tablet, every 6 hours for 5 days starting the day of the nail procedure
Participants will receive Acetaminophen administered orally at a dose of 650 mg every 6 hours for 5 days starting the day of the nail procedure. Alternate with ibuprofen 400 mg every 6 hours for 5 days starting day of nail procedure
Sponsors
University of Miami
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients age 18+ able to understand and provide written consent in English or Spanish who present to Dr. Brian Morrison's clinic at the University of Miami and are undergoing a nail unit procedure.
Exclusion criteria
* Patients under the age of 18 or adults unable to consent. * Patients who are pregnant or incarcerated.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Post-Operative Pain Intensity | 24 hours post nail procedure, 48 hours post nail procedure, 72 hours post nail procedure | Pot-operative pain intensity measured using the Numeric Rating Scale (NRS, 0-10), where 0 indicates no pain and 10 indicates worst possible pain; higher scores indicate greater pain following nail unit procedures. |
Countries
United States
Contacts
CONTACTBrian W Morrison, MD
PRINCIPAL_INVESTIGATORBrian Morrison, MD
University of Miami
Outcome results
None listed