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Ice Application for Oxacillin-Related Phlebitis and Pain

Effect of Ice Application on Reducing Peripheral Vascular Phlebitis and Pain After Oxacillin Injection: A Randomized Single-Blind Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07820956
Enrollment
86
Registered
2026-09-15
Start date
2022-04-07
Completion date
2022-12-31
Last updated
2026-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injection Site Pain, Pain, Peripheral Intravenous Phlebitis

Keywords

Oxacillin, Ice Application, Peripheral Intravenous Catheter, Phlebitis, Pain, Cryotherapy

Brief summary

This randomized controlled trial evaluated whether ice application could reduce pain and peripheral intravenous phlebitis associated with oxacillin administration. Hospitalized patients receiving intravenous oxacillin were assigned to either an ice application group or a control group. In the intervention group, ice was applied to the area around the peripheral intravenous catheter before oxacillin administration. In the control group, a room-temperature water bag was applied in the same manner. Pain after oxacillin administration and signs of phlebitis at the intravenous catheter site were assessed and compared between the two groups. The study aimed to determine whether ice application could provide a simple, non-pharmacological approach to reducing oxacillin-related pain and phlebitis.

Interventions

Ice was applied around the peripheral intravenous catheter site before intravenous oxacillin administration. The intervention was intended to reduce pain associated with oxacillin administration and the occurrence of peripheral intravenous phlebitis.

OTHERRoom-Temperature Water-Bag Application

A room-temperature water bag was applied around the peripheral intravenous catheter site before intravenous oxacillin administration as the control condition.

Sponsors

Central Taiwan University of Science and Technology
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

Adults aged 20 to 60 years. Conscious and able to participate in the study. Intravenous injection site located on either hand. Receiving a single antibiotic medication during the study. Eligible regardless of sex or medical diagnosis.

Exclusion criteria

Dementia. Psychiatric disorders. Skin rash at the study site. Purpura. Pregnancy. Current oral corticosteroid use. Hemodialysis. Administration of a second medication or an injection containing two or more medications during the study. \-

Design outcomes

Primary

MeasureTime frameDescription
Pain Intensity After Intravenous Oxacillin AdministrationUp to 72 hours after intravenous oxacillin administrationPain intensity associated with intravenous oxacillin administration was assessed repeatedly after oxacillin administration across nine 8-hour intervals during the 72-hour observation period. Higher pain scores indicated greater pain intensity.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 16, 2026