A Multicenter Prospective Observational Study of Acute Ischemic Stroke in Patients With Active Cancer

Clinical Characteristics and Stroke Recurrence in Patients With Acute Ischemic Stroke and Active Cancer: CAT-AIS Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07819526

Acronym

CAT-AIS

Enrollment

500

Registered

2026-09-15

Start date

2026-03-01

Completion date

2032-03-31

Last updated

2026-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Active Cancer, Acute Ichemic Stroke

Keywords

Cancer-associated ischemic stroke, Recurrent ischemic stroke, Cancer, Antithrombotic therapy

Brief summary

The goal of this multicenter prospective observational study, conducted at 24 hospitals in Japan, is to learn about recurrent ischemic stroke in people with active cancer who develop acute ischemic stroke. One of the main objectives is to evaluate how often ischemic stroke recurs during follow-up. The main questions this study aims to answer are: * How often does ischemic stroke recur within 3 months after the initial stroke? * Which clinical factors may be associated with recurrent ischemic stroke? * What other clinical outcomes occur during follow-up? Participants will receive medical care determined by their treating physicians. Researchers will collect information about participants' cancer, stroke characteristics, test results, treatments, recurrent ischemic stroke, and other clinical outcomes. Researchers will also explore whether clinical factors are associated with recurrent ischemic stroke and other outcomes. This study will not assign participants to a specific treatment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Acute ischemic stroke diagnosed within 7 days after symptom onset or the time last known well. 2. Active cancer at the time of the index stroke, as defined below.

Exclusion criteria

1. The patient or a legally acceptable representative indicates that the patient does not wish to participate. 2. The investigator considers enrolment inappropriate.

Design outcomes

Primary

Measure	Time frame	Description
Percentage of Participants With Recurrent Ischemic Stroke Within 3 Months	From enrollment through 3 months of follow-up	The percentage of participants who experience recurrent ischemic stroke during follow-up. Recurrent ischemic stroke will be determined according to the criteria prespecified in the study protocol.

Countries

Japan

Outcome results