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C-Raven LDCT: Lung Cancer Screening Intervention

C-Raven LDCT: Pilot Randomized Control Trial (RCT) of a Lung Cancer Screening Intervention

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07819318
Acronym
C-Raven LDCT
Enrollment
300
Registered
2026-09-14
Start date
2026-10-15
Completion date
2027-08-30
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer Screening

Keywords

tobacco, smoking, lung cancer, cancer screening

Brief summary

This study is a three-arm, randomized controlled pilot of a lung cancer screening intervention. The investigators will recruit participants ages 50-80 who are likely to meet lung cancer screening guidelines. After eligibility screening, participants will be randomized to one of three educational interventions regarding lung cancer. Lung cancer screening outcomes will be assessed.

Detailed description

Smoking is associated with a dramatically increased risk of lung cancer, with rates 10-40 times higher among those who smoke than among those who do not smoke, with smoking accounting for about 85-90% of all lung cancer cases. Screening for lung cancer with low-dose computed tomography (LDCT) has been shown to significantly reduce lung cancer mortality in high-risk populations. Lung cancer screening with annual LDCT is therefore recommended by the US Preventive Services Task Force (USPSTF) for all adults aged 50 to 80 years with a 20 pack-year history of smoking who currently smoke or have quit within the past 15 years. However, in a nationwide study of individuals eligible for lung cancer screening in 2022, only 18% were up-to-date with the recommended screening. The investigators propose a three-arm, randomized controlled pilot of a lung cancer screening intervention. Recruitment will be carried out primarily through the electronic health record, with invitations sent to patients aged 50-80 who have a documented history of smoking but no chest CT on file within the past 18 months. The investigators will also partner with community organizations such as senior centers and churches to distribute information about the study. Potential participants will be screened for eligibility for lung cancer screening. If eligible, the participants will undergo a consent process, complete baseline surveys (demographics, etc.), and be randomized to one of the following three study conditions: 1. Notification of eligibility for lung cancer screening with a recommendation to discuss with the participant's health care provider 2. Animated video on shared decision-making for LDCT with accompanying guide, offered as a downloadable PDF or mailed hard copy, per individual preference 3. Video and guide as in (b), plus a one-on-one call with a community health worker (CHW), 1-2 weeks after viewing the materials Three months after receiving the intervention, follow-up surveys will be sent to assess attitudes toward and completion of lung cancer screening.

Interventions

BEHAVIORALVideo/Brochure

Brief animated video that covers the basics of lung cancer screening and shows shared decision-making. An accompanying brochure uses images and information from the video to reinforce concepts (delivered via PDF or mail, per participant preference).

BEHAVIORALVideo/Brochure/Follow-up Call

Brief animated video that covers the basics of lung cancer screening and shows shared decision-making. An accompanying brochure uses images and information from the video to reinforce concepts (delivered via PDF or mail, per participant preference). A follow-up call with a community outreach specialist/community health worker is made 1-2 weeks after the initial intervention to check in on participant plans regarding lung cancer screening and to assist with any barriers.

Sponsors

Johns Hopkins University
Lead SponsorOTHER
Maryland Cigarette Restitution Fund
CollaboratorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Existing record within the Johns Hopkins medical system * Age 50-80 * Current tobacco use OR cessation within the past 15 years * 20-pack year history of smoking * No chest CT imaging within the past 18 months * English speaking * Willing to complete the study procedures, which include questionnaires and possibly a follow-up call

Exclusion criteria

* Not meeting eligibility criteria

Design outcomes

Primary

MeasureTime frameDescription
Number of Participants with Completion of Lung Cancer Screening3 monthsSelf-reported completion of low dose chest CT for lung cancer screening during the study follow-up period

Secondary

MeasureTime frameDescription
Number of Participants with Clinician Discussion on Lung Cancer Screening3 monthsSelf-reported conversation with clinician about lung cancer screening during the study follow-up period
Number of Participants with Change in Intent to obtain lung cancer screening3 monthsChange in intent to obtain lung cancer screening

Contacts

CONTACTAlejandra Ellison-Barnes, MD, MPH
aelliso6@jhmi.edu410-955-5000
CONTACTHeidi Hutton, PhD
hhutton@jhmi.edu443-287-2874
PRINCIPAL_INVESTIGATORAlejandra Ellison-Barnes, MD, MPH

Johns Hopkins University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 15, 2026