Value of Optic Nerve Sheath Diameter in Differentiating Ischemic From Hemorrhagic Stroke

Diagnostic Value of Bedside Ultrasonographic Optic Nerve Sheath Diameter Measurement in Differentiating Ischemic From Hemorrhagic Stroke in the Emergency Department

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07818408

Enrollment

Registered

2026-09-14

Start date

2021-04-01

Completion date

2021-12-31

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular Accident (Stroke)

Keywords

optic nerve sheath diameter, stroke, ultrasonography

Brief summary

We aimed to examine bedside ONSD values measured by ocular ultrasonography in patients presenting to the ED with stroke, and to determine a diagnostic cut-off value for differentiating ischemic from hemorrhagic stroke.

Detailed description

This study was conducted prospectively and observationally in the adult emergency department of a tertiary training and research hospital. Patients older than 18 years who presented to the ED with stroke on the investigator's shift days, who were not followed up or treated by the investigator, and who were diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI) were included in the study. Patients who were intubated, those who were unwilling to participate, and those in whom mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, optic neuritis, or any cause that could lead to cerebral edema or affect the ONSD by raising ICP was identified in their history or on imaging were excluded.

Interventions

DIAGNOSTIC_TESTBedside Ocular Ultrasonography (ONSD Measurement)

Measurement of the optic nerve sheath diameter using a high-frequency (4-10 MHz) linear probe at 3 mm posterior to the papilla, immediately after the CT/MRI procedure.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients older than 18 years presenting to the ED with stroke. * Patients diagnosed with cerebrovascular disease (CVD) by radiological imaging (CT/MRI).

Exclusion criteria

* Patients who are intubated. Patients unwilling to participate. * History or imaging findings of mass, aneurysm, metastasis, hydrocephalus, sarcoidosis, ventriculoperitoneal shunt, or optic neuritis. * Any condition leading to cerebral edema or affecting ONSD by independently raising intracranial pressure.

Design outcomes

Primary

Measure	Time frame	Description
Cut-off Value of Optic Nerve Sheath Diameter (ONSD)	Evaluated immediately following the initial imaging procedure (CT/MRI) in the emergency department.	Determination of the optimal ONSD cut-off value (in millimeters) to effectively differentiate between ischemic and hemorrhagic stroke subtypes.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 15, 2026