Headache, Migraine
Conditions
Keywords
Transgender Persons, Gender Diverse Persons, Gender-Affirming Hormone Therapy, Gender-Affirming Surgery, HIV Pre-Exposure Prophylaxis, Headache Prevalence, Migraine Prevalence
Brief summary
The goal of this observational study is to learn how common headache and migraine are and to describe headache patterns among transgender adults in Thailand. The main questions it aims to answer are: * How common are headache and migraine among transgender adults in Thailand? * What headache patterns and levels of headache-related disability do participants report? * Are gender-affirming hormone therapy, gender-affirming surgery, or HIV pre-exposure prophylaxis (PrEP) use related to headache or migraine? About 500 transgender adults aged 18 years or older who currently attend or previously attended the Tangerine Clinic in Bangkok, Thailand, will take part. Participants will: * Provide consent online * Complete an online questionnaire about their general health and headache symptoms * Answer questions about gender-affirming hormone therapy, gender-affirming surgery, and PrEP use * Complete questionnaires that screen for migraine and measure how headaches affect daily activities This study will not assign any treatment or change the participants' usual medical care.
Interventions
Current or previous use of gender-affirming hormone therapy as part of the participant's usual care. Information about medication name, dose, route, frequency, duration, and adherence will be collected through an online questionnaire. The researchers will not assign or modify hormone therapy.
PROCEDUREGender-Affirming Surgery
History of gender-affirming surgery received as part of the participant's usual care. The type and date of surgery will be collected through an online questionnaire. No surgical procedure will be assigned or performed as part of this study.
DRUGHIV Pre-Exposure Prophylaxis
Current or previous use of HIV pre-exposure prophylaxis as part of the participant's usual care. Information about PrEP use will be collected through an online questionnaire. The researchers will not prescribe or modify PrEP as part of this study.
Sponsors
Chulalongkorn University
Institute of HIV Research and Innovation Foundation, Thailand
International Headache Society
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age 18 years or older * Self-identifies as transgender * Currently attends or has previously attended the Tangerine Clinic in Bangkok, Thailand * Able to understand the study information and provide electronic informed consent * Able to complete the online study questionnaire
Exclusion criteria
* Alcohol or drug use, or a medical condition that, in the investigator's judgment, could interfere with completion of the study procedures or the ability to provide informed consent * A medical condition known to cause a secondary headache disorder unrelated to migraine, such as head trauma, a structural brain lesion, or an infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Headache | At enrollment during the one-time online questionnaire | Number and percentage of participants who report headache in 1 year based on the structured online headache questionnaire. |
| Clinical Characteristics of Headache | At enrollment during the one-time online questionnaire | Number and percentage of participants reporting headache characteristics, including headache location, pain quality, aggravation by physical activity, nausea or vomiting, sensitivity to light, sensitivity to sound, aura symptoms, and reported headache triggers. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Migraine | At enrollment during the one-time online questionnaire | Number and percentage of participants who screen positive for migraine based on the ID Migraine and American Migraine Prevalence and Prevention/American Migraine Study questionnaires. |
| Headache-Related Disability Assessed Using the Migraine Disability Assessment Questionnaire | During the 3 months before enrollment | Headache-related disability measured using the total Migraine Disability Assessment (MIDAS) score. Higher scores indicate greater headache-related disability. |
| Association Between Gender-Affirming Hormone Therapy Use and Headache | At enrollment during the one-time online questionnaire | Association between current or previous gender-affirming hormone therapy (GAHT) use and the presence of headache, as assessed by a self-reported headache item in the study questionnaire. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
| Association Between Gender-Affirming Surgery and Headache | At enrollment during the one-time online questionnaire | Association between a history of gender-affirming surgery and the presence of headache, as assessed by a self-reported headache item in the study questionnaire. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
| Association Between HIV Pre-Exposure Prophylaxis Use and Headache | At enrollment during the one-time online questionnaire | Association between current or previous HIV pre-exposure prophylaxis (PrEP) use and the presence of headache, as assessed by a self-reported headache item in the study questionnaire. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
| Association Between Gender-Affirming Hormone Therapy Use and Migraine | At enrollment during the one-time online questionnaire | Association between current or previous gender-affirming hormone therapy (GAHT) use and the presence of migraine, assessed using the ID Migraine and American Migraine Prevalence and Prevention/American Migraine Study questionnaires.. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
| Association Between Gender-Affirming Surgery and Migraine | At enrollment during the one-time online questionnaire | Association between a history of gender-affirming surgery and the presence of migraine, as assessed by the ID Migraine and American Migraine Prevalence and Prevention/American Migraine Study questionnaires. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
| Association Between HIV Pre-Exposure Prophylaxis Use and Migraine | Time Frame: At enrollment during the one-time online questionnaire | Association between current or previous HIV pre-exposure prophylaxis (PrEP) use and the presence of migraine, as assessed by the ID Migraine and American Migraine Prevalence and Prevention/American Migraine Study questionnaires. The association will be estimated using logistic regression and reported as an odds ratio with a 95% confidence interval. Unit of Measure: Odds ratio |
Countries
Thailand
Contacts
CONTACTPrakit Anukoolwittaya, M.D.
CONTACTSirawit Roongrojwittayakul, M.D.
PRINCIPAL_INVESTIGATORPrakit Anukoolwittaya, M.D.
Chulalongkorn University
PRINCIPAL_INVESTIGATORSirawit Roongrojwittayakul, M.D.
Ratchaburi Hospital
STUDY_DIRECTORAkarin Hiransuthikul, M.D., M.Sc.
Chulalongkorn University
STUDY_DIRECTORSekh Thanprasertsuk, M.D.
Chulalongkorn University
STUDY_DIRECTORJakkrapatara Boonruang, M.D.
Institute of HIV Research and Innovation
Outcome results
None listed