Non Valvular Atrial Fibrillation
Conditions
Keywords
Left Atrial Appendage (LAA)
Brief summary
This study is intended to evaluate the safety and feasibility of the Append System for left atrial appendage (LAA) elimination using a transcatheter procedure that invaginates and ligates the LAA tissue.
Detailed description
The objective of this study is to evaluate the safety and performance of the Append System in patients with non-valvular atrial fibrillation who are considered appropriate candidates for LAA closure to reduce the risk of thromboembolism originating from the LAA. The Append System is designed to eliminate the LAA without the use of a permanent metallic implant. The procedure is performed via a transfemoral, transseptal, transcatheter approach. During the procedure, the LAA is invaginated into the left atrium (LA), and the inverted tissue is ligated using a standard surgical suture, resulting in elimination of the LAA cavity. Patients will be followed for up to 5 years after the procedure to assess safety, device performance, and long-term outcomes.
Interventions
DEVICEAppend System
Elimination of the left atrial appendage using the Append System through a transcatheter procedure involving invagination and ligation of the LAA tissue.
Sponsors
Append Medical Ltd.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants will be prospectively enrolled into one of two predefined clinical cohorts based on the treating physician's procedural strategy: Append with concomitant standard-of-care atrial fibrillation (AF) ablation or Append-only procedure. All participants receive the Append System intervention, and the same study endpoints are assessed across both cohorts.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male or non-pregnant female aged ≥18 years 2. Documented non-valvular AF (paroxysmal, persistent, permanent or non-rheumatic valve-related AF) 3. The subject has a calculated CHA2DS2-VASc score of 2 or greater for males or 3 or greater for females. 4. The subject is eligible for the defined protocol medication regimen of anticoagulation and antiplatelet therapy following Append procedure. 5. The patient is deemed appropriate for LAA ligation by the screening committee and the investigator. 6. The patient has been informed of the nature of the study, agrees to its provisions \& follow-up evaluations, and has provided written informed consent approved by the appropriate Institutional Review Board (IRB) or Ethics Committee (EC).
Exclusion criteria
1. Pregnant or nursing patients and those who plan pregnancy in the period up to 1 year following the index procedure. Female patients of childbearing potential must have a negative pregnancy test (per site standard test) within 7 days prior to index procedure. 2. Atrial fibrillation that is defined by a single occurrence or that is considered to be reversible (e.g., due to thyroid disorders, acute alcohol intoxication, trauma, or recent major surgical procedures). 3. Patients with an indication for chronic oral anticoagulation other than AF (e.g., history of unprovoked deep vein thrombosis or pulmonary embolism, or mechanical heart valve) 4. Clinically significant Severe heart failure (New York Heart Association functional class IV) 5. Prior cardiac surgery or surgery requiring sternotomy 6. Recent (within 3 months pre-procedure) stroke or transient ischemic attack. 7. Recent (within 3 months pre-procedure) myocardial infarction 8. Recent (within 30 days before the index procedure) or planned (within 60 days after the index procedure) cardiac interventional procedures (e.g., percutaneous coronary intervention, structural heart valve procedures, etc.), not including catheter ablation. 9. Planned (within 60 days after the index procedure) cardiac surgical procedures or any surgeries which require sternotomy. 10. Recent (within 30 days before the index procedure) or planned (within 60 days after the index procedure) noncardiac procedures or surgical interventions. 11. History of symptomatic pericarditis (acute or chronic). 12. Patient has evidence of cardiac tumor 13. Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation), or dialysis at the time of screening 14. Platelet count \<50,000 cells/mm3 or \>700,000 cells/mm3, or white blood cell count \<3,000 cells/mm3 or known Bleeding diathesis 15. Active infection with bacteremia 16. Patient has a known allergy, hypersensitivity or contraindication to aspirin, heparin, or that would preclude any P2Y12 inhibitor therapy, or the patient has contrast sensitivity that cannot be adequately pre-medicated 17. Current participation in another investigational drug or device study that would interfere with this study 18. Patient is unable to undergo general anesthesia 19. Patient has a condition which precludes adequate transesophageal echocardiographic (TEE) or computed tomographic (CT) assessment. 20. Known other medical illness or known history of substance abuse that may cause non-compliance with the specified medication regimen, confound the data interpretation, or is associated with a life expectancy of less than 5 years. Cardiac Imaging
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composite major adverse events | 30 days | Composite rate of major adverse events related to the device or procedure, including all-cause mortality, ischemic stroke, systemic embolism, and cardiac tamponade or pericardial effusion requiring drainage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Composite major adverse events | 6 months | Composite rate of major adverse events related to the device or procedure, including all-cause mortality, ischemic stroke, systemic embolism, pericardial effusion requiring drainage, major bleeding (BARC 3/ BARC 5), hemorrhagic stroke, and device or procedure-related events requiring open cardiac surgery or major endovascular intervention such as pseudoaneurysm repair, AV fistula repair, or other major endovascular repair |
Countries
Czechia
Contacts
CONTACTLiz Zinger, MSc
Outcome results
None listed