Gastrointestinal Cancer, Frailty
Conditions
Keywords
Fried Frailty Index, Clinical Frailty Scale, Preoperative Frailty, Postoperative Complications
Brief summary
This prospective observational cohort study will evaluate whether preoperative frailty, assessed using the Fried Frailty Index and the Clinical Frailty Scale, is associated with postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer. Participants will be followed for 90 days after surgery. Postoperative complications, length of hospital stay, and mortality at 30 and 90 days will be recorded. The study aims to determine the prognostic value of these frailty assessment tools for identifying patients at increased risk of adverse postoperative outcomes.
Detailed description
Frailty is associated with reduced physiological reserve and may increase the risk of adverse outcomes following major surgery, particularly in older patients with cancer. Preoperative recognition of frailty may assist clinicians in risk assessment, perioperative planning, and postoperative monitoring. This single-center prospective observational cohort study will include approximately 80-100 patients aged 60 years or older who are scheduled to undergo elective surgery for gastrointestinal cancer at Van Training and Research Hospital. Before surgery, each participant's frailty status will be assessed using the Fried Frailty Index and the Clinical Frailty Scale. Demographic and clinical characteristics, including age, sex, cancer diagnosis, and relevant perioperative variables, will also be recorded. Participants will receive routine clinical care, and no treatment or surgical intervention will be assigned by the study protocol. Patients will be followed for 90 days after surgery. Recorded postoperative outcomes will include length of hospital stay, surgical and medical complications, 30-day mortality, and 90-day mortality. The associations between preoperative frailty scores and postoperative outcomes will be analyzed to evaluate and compare the prognostic performance of the two frailty assessment tools.
Interventions
DIAGNOSTIC_TESTFried Frailty Index
Frailty will be assessed preoperatively using the Fried Frailty Index. The assessment evaluates established frailty components, including unintentional weight loss, exhaustion, low physical activity, slow walking speed, and reduced grip strength. The assessment will not determine or modify the participant's treatment.
DIAGNOSTIC_TESTClinical Frailty Scale
Frailty will be assessed preoperatively using the Clinical Frailty Scale, which classifies the participant's overall level of fitness and frailty based on clinical evaluation. The assessment will not determine or modify the participant's treatment.
Sponsors
Van Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 60 years or older * Diagnosed with gastrointestinal cancer * Considered operable and scheduled to undergo elective surgery * Evaluated at the General Surgery Clinic of Van Training and Research Hospital * Willing to participate and provide informed consent
Exclusion criteria
* Younger than 60 years * Undergoing emergency surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Postoperative Complications | From the date of surgery through postoperative day 90 | The proportion of participants who develop at least one postoperative surgical or medical complication. Recorded complications will include anastomotic leakage, wound-related complications, intolerance of oral intake, delayed mobilization, and other clinically documented postoperative complications. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Length of Hospital Stay | From the date of surgery to hospital discharge, assessed up to 90 days after surgery | The number of days from the date of surgery to hospital discharge. |
| All-Cause Mortality Within 30 Days After Surgery | From the date of surgery through postoperative day 30 | The proportion of participants who die from any cause within 30 days after surgery. |
| All-Cause Mortality Within 90 Days After Surgery | From the date of surgery through postoperative day 90 | The proportion of participants who die from any cause within 90 days after surgery. |
Countries
Turkey (Türkiye)
Contacts
CONTACTİbrahim Doğan, MD
Outcome results
None listed