Erectile Dysfunction and Coronary Artery Disease
Conditions
Keywords
Association between ED and CAD
Brief summary
This study provides a comprehensive bidirectional assessment to determine the prevalence, clinical severity, and anatomical correlation between erectile dysfunction and coronary artery disease severity in patients presenting to cardiology and sexual health pathways.
Detailed description
Erectile dysfunction (ED) and coronary artery disease (CAD) share a common pathophysiological substrate predominantly driven by systemic endothelial dysfunction, vascular inflammation, and atherosclerosis. Under the "artery size hypothesis," atherosclerotic plaque accumulation leads to clinical symptoms earlier in smaller vessels than in larger ones. Because penile cavernosal arteries are smaller in diameter (1-2 mm) compared to the proximal left anterior descending coronary artery (3-4 mm), lumen obstruction typically manifests as erectile impairment before overt coronary symptoms surface. Consequently, assessing erectile health provides a critical non-invasive window into systemic vascular disease and serves as an early clinical marker for cardiovascular risk stratification. The 2021 European Society of Cardiology (ESC) Guidelines on cardiovascular disease prevention explicitly mandate evaluating organic ED as an independent risk modifier for silent cardiovascular disease.
Interventions
OTHERSelective Coronary Angiography
Diagnostic invasive coronary angiography performed to evaluate coronary anatomy, presence of stenosis, and anatomical severity scores (SYNTAX Score and Gensini Score).
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1 - Male patients aged between 18 and 50 years. 2-Patients undergoing primary or diagnostic coronary angiography due to suspected or confirmed acute, chronic coronary syndrome or stable angina. 3-Patients providing written informed consent to participate in the study and discuss sexual health assessments.
Exclusion criteria
1. Patients presenting with cardiogenic shock, unstable hemodynamics. 2. Primary psychogenic, endocrinological (except diabetes mellitus), or neurogenic erectile dysfunction. 3. Prior history of pelvic surgery, pelvic trauma, or radical prostatectomy. 4. Severe hepatic failure, end-stage renal disease on dialysis, or active malignancies. 5. Decompensated heart failure (NYHA Class III or IV).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bidirectional Assessment of Erectile Dysfunction and Coronary Artery Disease: Prevalence, Severity, and Clinical Correlation | Baseline | To determine the prevalence and clinical severity of erectile dysfunction (using the International Index of Erectile Function-5, IIEF-5) in patients diagnosed with coronary artery disease undergoing coronary angiography, and conversely, to assess the prevalence and anatomical severity of CAD in patients presenting with vasculogenic severe ED. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bidirectional Assessment of Erectile Dysfunction and Coronary Artery Disease: Prevalence, Severity, and Clinical Correlation | Baseline | To correlate the severity of ED (IIEF-5 score) with the anatomical complexity and severity of CAD evaluated by coronary angiography (using the SYNTAX score or Gensini score). To evaluate echocardiographic parameters (e.g., left ventricular ejection fract |
Contacts
CONTACTIbrahim Atta Ibrahim, Master degree
Outcome results
None listed