Alveolar Bone Loss
Conditions
Keywords
Mineralized Dentin Graft, Autogenous Tooth-Derived Graft, Beta-Tricalcium Phosphate, Tooth Extraction, Cone-Beam Computed Tomography, Histomorphometry, Alveolar Ridge Preservation
Brief summary
The goal of this clinical trial was to compare three ways of helping the jawbone heal after removal of a tooth. The jawbone that supports a tooth is called the alveolar ridge. This bone can become narrower after a tooth is removed. Participants were randomly assigned to one of three groups. One group received no bone graft material. One group received mineralized dentin graft made from the participant's extracted tooth. One group received beta-tricalcium phosphate, which is a synthetic bone graft material. Participants had cone-beam computed tomography, a three-dimensional dental X-ray, immediately after tooth removal and again after 6 months. During dental implant placement at 6 months, researchers collected a small bone sample to examine healing.
Detailed description
After tooth extraction, the alveolar ridge undergoes natural remodeling that can reduce its width and affect future dental implant placement. Alveolar ridge preservation aims to limit these dimensional changes. This randomized controlled clinical trial compared autogenous mineralized dentin graft, beta-tricalcium phosphate, and healing without bone graft material following extraction of hopeless maxillary teeth. Participants were randomly assigned in a 1:1:1 ratio to three groups. The control group received no bone graft material. The mineralized dentin graft group received graft particles prepared from the participant's extracted tooth. The beta-tricalcium phosphate group received a synthetic bone graft material. Alveolar ridge width was measured using cone-beam computed tomography immediately after extraction and at 6 months. During delayed dental implant placement at 6 months, a small bone-core sample was collected from each study site.
Interventions
PROCEDUREAlveolar Ridge Preservation With Autogenous Mineralized Dentin Graft
Following atraumatic tooth extraction, an autogenous mineralized dentin graft prepared chairside from the participant's extracted tooth is placed in the extraction socket.
PROCEDUREAlveolar Ridge Preservation With Beta-Tricalcium Phosphate
Following atraumatic tooth extraction, beta-tricalcium phosphate granules are placed in the extraction socket.
PROCEDUREExtraction Socket Healing Without Bone Graft
Following atraumatic tooth extraction, no bone graft material is placed in the extraction socket.
Sponsors
Soaad Tolba Mohammed Tolba Badawi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Participants and the radiographic and histomorphometric outcome assessors were masked to group assignment. The statistician was also masked. The operating surgeon could not be masked and learned the group assignment after tooth extraction when the sealed allocation envelope was opened.
Intervention model description
Three-arm, parallel-group randomized controlled trial in which extraction sites were allocated in a 1:1:1 ratio to healing without bone graft material, autogenous mineralized dentin graft, or beta-tricalcium phosphate.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 18 years or older. * Clinical indication for extraction of a hopeless maxillary tooth. * No evidence of acute infection at the intended extraction site. * Willing and able to comply with the scheduled study visits and follow-up procedures. * Provided written informed consent.
Exclusion criteria
* Systemic disorder known to impair bone metabolism. * History of radiotherapy involving the head and neck region. * Pregnancy or lactation. * Advanced periodontal disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Alveolar Bone Width From Baseline to 6 Months | Baseline immediately after tooth extraction and 6 months | Alveolar bone width was measured in millimeters using cone-beam computed tomography immediately after tooth extraction and at 6 months. Width was measured horizontally from the outer buccal cortical surface to the palatal cortical surface. |
Countries
Egypt
Outcome results
None listed